TRASNCONJUNCTIVAL INJECTION OF PRP IN LACRIMAL GLAND FOR SEVERE DRY
EYE DISEASE-CASE REPORT
Published 2023
- 27th ESCRS Winter Meeting
Reference: P210
| Type: Case Report (Cornea Day)
| DOI:
10.82333/pjt5-e126
Authors:
Anita Syla Lokaj* 1
, Faruk Semiz 1
, Njomza Hima Musa 1
, Ceren Ece Semiz 1
, Gokce Idil Semiz 1
, Zekerya Alp Demirsoy 1
, Olcay Semiz 1
1Ophthalmology,Eye Hospital,Prishtine,Albania
Purpose
Purpose: The purpose of this study is to assess the efficacy of the injections of platelet rich
plasma (PRP) for the treatment of severe dry eye disease(DED), and to compare with topical free
preservative PRP in other eye.
Setting
Eye Hospital,Departmen of Ophthalmology,Prishtinë,Kosova
Report of case
Methods: This case report, included a patient with severe dry eye who had been diagnosed with
Sjogren syndrome. The patient previously used artificial tears, autologous serum, but without
improvement. We decide that in one eye we will inject transconjunctival every month for 3
months e-PRP, while in the other eye we will prepare drops for topical application.The right eye
received 1ml transconjunctivally injection at day 0, 30, 60 and 90 while in the other eye we
applied PRP drops 5 times a day for about 3 months .Two eyes were measured at baseline and at
30, 60 and 90 days. The primary outcome measures were changes in corneal staining according
to the Oxford classification, results of the Schirmer test and tear break-up time (TBUT).
Results: Symptoms of dry eye, changes in corneal transparency and other changes were
significantly improved in the injcetion plasma eye compared to conventional topical PRP eye
drops.The SCHIRMER test increased by several points. Primary outcomes are fluorescein break-
up time, Schirmer’s I test, and TBUT. No complications were observed during short term follow-
up.
Conclusion / Take home message
Conclussion: It can be concluded from this study that the therapeutic response with injection
tranconjunctivally PRP was actually satisfactory in severe or moderate dry
eye cases which comparing to conventional therapy with topical drops of PRP. Injection of PRP
in lacrimal gland is simple, safe, and effective technique in treatment of severe dry eye; proved
by improvement of tear film parameters through subjective and objective assessment.
This represent a novel alternative treatment for severe dry eye disease.