Cyclo Mix: A Combined Technique For The Application Of Transscleral Cyclophotocoagulation In Patients With Uncontrolled Advanced Glaucoma.

To describe the short-term outcomes of a Cyclo Mix technique in uncontrolled advanced glaucoma cases.

A retrospective non-comparative study conducted in the ophthalmology department at Hillel Yaffe Medical Center, Israel.

A combined technique for the application of transscleral cyclophotocoagulation was performed using the subliminal mode (Subthreshold) in one hemifield, and the continuous wave mode (Thermal) on the other hemifield. Patients were followed-up for 3 months and primary outcomes were mean intraocular pressure (IOP) change and number of glaucoma medications.

11 eyes of 8 patients with uncontrolled advanced glaucoma treated with Cyclo Mix between March and December 2021 were included. Mean age was 62.6±21.4 (range: 24-86), with a baseline IOP of 34.5±16.2 (range: 21-65 mmHg) and a mean of 3.9 glaucoma medications. During the follow-up period, 2 patients had resistant uncontrolled IOP and needed further surgical interventions. Of the other 9 eyes, at the end of follow-up mean IOP reduction was -41.3%±15.9%, and mean number of glaucoma medication was 3.5.

Cyclo Mix seems to effectively reduce IOP in uncontrolled advanced glaucoma cases, although most of our patients needed to continue most of their glaucoma medications. Further studies with larger population and longer follow-up are warranted for the evaluation of this combined technique.