ESCRS - PE032 - Diabetic Foveal Avascular Zone - Differences Between High Speed And High Resolution Scans

Diabetic Foveal Avascular Zone - Differences Between High Speed And High Resolution Scans

Published 2022 - 40th Congress of the ESCRS

Reference: PE032 | Type: ESONT - Abstract | DOI: 10.82333/wca0-mb92

Authors: Bruno Pereira* 1 , Inês Anacleto 2 , João Pires 2 , Verónica Santos 2 , Catarina Tarracha 2 , Teresa Varandas 3 , Pedro Camacho 4

1Instituto de Retina de Lisboa,Lisbon,Portugal;Nova Medical School,Lisbon,Portugal;ESTeSL,Lisbon,Portugal, 2ESTeSL,Lisbon,Portugal, 3Nova Medical School,Lisbon,Portugal;APDP,Lisbon,Portugal, 4ESTeSL,Lisbon,Portugal;Institute of Ophthalmology Dr. Gama Pinto,Lisbon,Portugal;Nova Medical School,Lisbon,Portugal

Purpose

Diabetic Retinopathy is one of the causes for pathological increase of the Foveal Avascular Zone (FAZ) area, assessable by optical coherence tomography angiography (OCTA). Our aim is to evaluate the differences in FAZ area comparing two different OCTA acquisition protocols.

Setting/Venue

H&TRC- Health & Technology Research Center, ESTeSL - Escola Superior de Tecnologia da Saúde de Lisboa, IRL - Instituto de Retina de Lisboa

Methods

This cross-sectional study recruited 27 participants (7 cases persistent DME, 9 cases with good DME response, and 11 controls), participants of a study regarding differential DNA methylation in persistent Diabetic Macular Edema.  Two different OCT-A scans were acquired, a 10ºx10º HR OCT-A scan and a 20ºx20º HS OCT-A Scan, both centered in the fovea. Two observers manually measured twice the FAZ area in the superficial vascular complex (SVC) and deep vascular complex (DVC) on each HR and HS scans. Differences between the different FAZ area measurements were analysed

Results

A total of 27 eyes from 27 patients (55% women) aged 59–91 years were studied. Measurements of the FAZ area were compared between different retinal plexus, between the two different protocols and also between the different patient groups. On average, FAZ area measurement was higher using HS scans compared to HR scans (differences betweeen HS and HR were 0,112±0,053 mm2 in the SVC and 0,087±0,037 mm2 in the DVC).

Conclusions

The results of this study will contribute to the comparison between different OCT-A acquisition protocols, to evaluate the most reliable acquisition protocol and analysis of the FAZ area when dealing with diabetic patients.