ESCRS - FPT04.10 - Potential Predictive Biomarkers For Exacerbated Retinal Pathologies Post Cataract Surgery

Potential Predictive Biomarkers For Exacerbated Retinal Pathologies Post Cataract Surgery

Published 2022 - 40th Congress of the ESCRS

Reference: FPT04.10 | Type: Free paper | DOI: 10.82333/q6dt-w429

Authors: Naren Shetty* 1 , Rohit Shetty 1 , Arkasubhra Ghosh 1 , Swaminathan Sethu 1 , Reshma RAnade 1 , Pooja Khamar 1

1Narayana Nethralaya,Bengaluru,India

Purpose

To determine if molecular factors and imaging markers can predict post-cataract surgery (CS) retinal pathologies.

Setting

Tertiary eye hospital, India 

Methods

Retinal pathologies were determined by fundus and OCT imaging. 224 patients were enrolled for the study and Aqueous humor (AH) soluble factor profile was analysed in 76 samples collected from patients undergoing Cataract surgery.  Biomarkers including VEGF and inflammatory mediators were determined by multiplex ELISA using flow cytometry. 

Results

Subjects with incidental mild retinal pathologies (pre-op) had altered levels of VEGF, FasL and IL-17F. Patients with diabetes and hypertension had significantly higher levels of VEGF and MCP1 compared to those with hypertension. Higher (P<0.05) levels of MIG, L-selectin, VCAM and FasL were observed in patients requiring treatment for retinal pathologies post cataract surgery. Increased levels of VEGF was also observed in this group of patients.

Conclusions

Patients who developed retinal pathologies post-CS had higher levels of inflammatory factors and VEGF  at the time of surgery, highlighting their value for monitoring and/or stratification.