ESCRS - P280 - QUANTITATIVE ANALYSIS OF PRECLINICAL OCULAR MICROVASCULAR CHANGES IN MULTISYSTEMIC INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

QUANTITATIVE ANALYSIS OF PRECLINICAL OCULAR MICROVASCULAR CHANGES IN MULTISYSTEMIC INFLAMMATORY SYNDROME IN CHILDREN (MIS-C) DETECTED BY OPTICAL COHERENCE TOMOGRAPHY ANGIOGRAPHY

Published 2022 - 26th ESCRS Winter Meeting

Reference: P280 | Type: Abstracts | DOI: 10.82333/ht1n-hv06

Authors: Busra Yilmaz Tugan* 1 , Hafize Emine Sonmez 2 , Levent Karabas 1 , Berna Ozkan 3 , Kubra Atay 1 , Evic Zeynep Basar 4

1Ophthalmology,Kocaeli University,Kocaeli,Türkiye, 2Pediatric Rheumatology,Kocaeli University,Kocaeli,Türkiye, 3Ophthalmology,Acıbadem Unversity,Istanbul,Türkiye, 4Pediatric Cardiology,Kocaeli University,Kocaeli,Türkiye

Purpose

To evaluate the macular and optic nerve head (ONH) vascular density, foveal avascular zone area, and outer retina and choriocapillaris flow in Multisystemic Inflammatory Syndrome in Children (MIS-C) using optical coherence tomography angiography (OCTA).

Setting

Kocaeli University Department of Ophthalmology and Department of Pediatric Rheumatology

Methods

Thirty-four eyes of 34 patients with MIS-C and 36 age and sex-matched healthy controls were investigated in this prospective, cross-sectional study. The superficial capillary plexus (SCP) and deep capillary plexus (DCP), ONH, FAZ parameters, the flow area of the outer retina, and choriocapillaris were evaluated using OCTA.

Results

All VD parameters in SCP were significantly lower in MIS-C patients. Although VD parameters of both DCP and ONH, as well as FAZ area and FAZ perimeter were lower in MIS-C group compared to the control group, these differences were not statistically significant. However, foveal density (FD-300) was significantly decreased in the MIS-C group. (p=0.024). The outer retina flow area at 1 mm, 2 mm, and 3 mm radius and CC flow area at 1 mm and 2 mm radius were significantly lower in the MIS-C group than in the control group. Although CC flow area at 3 mm radius was decreased in the MIS-C group compared to healthy controls, the difference was not statistically significant. 

Conclusion

We demonstrated a decreased vessel density in SCP, choriocapillaris flow area, and outer retinal flow area in MIS-C patients. Hence, we proposed that OCTA could reveal retinal microvascular changes in MIS-C patients who were completely healthy before the diagnosis of MIS-C.