ESCRS - P218 - IMPACT OF CIGARETTE SMOKING ON OCULAR SURFACE AND MEIBOMIAN GLAND FUNCTIONAL AND MORPHOLOGICAL CHARACTERISTICS

IMPACT OF CIGARETTE SMOKING ON OCULAR SURFACE AND MEIBOMIAN GLAND FUNCTIONAL AND MORPHOLOGICAL CHARACTERISTICS

Published 2022 - 26th ESCRS Winter Meeting

Reference: P218 | Type: Abstracts | DOI: 10.82333/0qfk-db15

Authors: Ana Rita Carreira* 1 , Sandra Rodrigues-Barros 1 , Júlia Cunha Silva 2 , Matilde Ferreira de Almeida 2 , Pedro Carreira 1 , Filipe Moraes 1 , Inês Machado 1 , Paul Campos 1 , João Cardoso 1 , Nuno Campos 1

1Ophthalmology,Hospital Garcia de Orta, E.P.E,Almada,Portugal, 2Pneumology,Hospital Garcia de Orta, E.P.E,Almada,Portugal

Purpose

Our aim was to assess the effect of smoking on ocular surface, tear film stability and meibomian gland functional and morphological characteristics.

Setting

Hospital Garcia de Orta E.P.E, Almada, Portugal

Methods

This study included healthy age-matched non-smokers and current cigarette smokers. Symptoms (Ocular Surface Disease Index (OSDI) questionnaire and symptoms score) and signs (Schirmer test I, Tear Film Break-up Time Test (TBUT), corneal fluorescein staining (CFS) score) of dry eye disease (DED) were determined. Lipid layer thickness (LLT) and Meibomian Gland Disfunction (MGD) grading were also assessed (slit-lamp examination and LipiView interferometer). 

Results

Twenty eyes were included in the Non-smokers group, with a mean age of 40.03±6.78 years, and 21 in the Smokers group, with a mean age of 42.24±3.51 years (p=0.08). Smokers group had higher proportion of DED diagnosis (10 vs 100%, p<0.001), with higher OSDI (10.60±2.12 vs 14.27±2.60, p=0.04) and CFS (3.01±0.42 vs 7.00±1.03, p=0.001) scores and lower TBUT values (12.23±1.34 vs 5.42±1.76s, p<0.001). MGD diagnosis proportion was higher in Smokers group (0 vs 47.62%, p<0.001), with greater Meibo-score (p<0.001) and lid abnormality score (p=0.01). LLT measurement was lower in Smokers group (64.02±1.87 vs 39.02±5.66nm, p=0.01). Smoking index was correlated with TBUT, Meibo-score and LLT (p<0.05).

Conclusion

Smoking negatively affected the ocular surface and meibomian glands, with a higher level of eye dryness, gland dropout and lipid tear film layer deficiency.