GIANT SQUAMOUS CORNEAL NEOPLASIA MONITORIZED WITH SPECTRAL-DOMAIN OPTIC COHERENCE TOMOGRAPHY (SD-OCT)

To describe a case of giant squamous corneal neoplasia monitorized with the aid of spectral-domain optic coherence tomography (SD-OCT).

A 95-year-old man presented with 5-months history of left eye (OS) pain. The anamnesis only revealed history of traumatic injury in OS with adequate vision recovery. Visual acuity in OS was amaurosis and slit-lamp examination demonstrated elevated nodular diffuse whitish mass completely covering the corneal surface, with neovascularization. High-resolution anterior segment module of SD-OCT showed hyperreflective corneal epithelium thickening, with maximum measurement of 385µ and no signs of deep corneal or intraocular invasion were observed. Clinical features strongly suggested giant squamous corneal neoplasia. Therefore, Interferon-α2b eyedrops 1MIU/mL 4/day were started with no identification of adverse effects.

A close follow-up with anterior segment color photographs and SD-OCT examinations was performed.

Complete recovery was achieved with no hyperreflectivity in corneal epithelium, 4 months later. Examination of anterior chamber was allowed, with subsequent white cataract detection. In this case, topical therapy treated successfully the entire ocular surface and avoided surgical intervention.. At 12-months follow-up, our patient remained clinically stable with no signs of squamous corneal neoplasia relapsing on SD-OCT.

Ocular surface squamous neoplasia encompasses a varied spectrum of disease involving abnormal growth of dysplastic squamous epithelial cells on the surface of the eye. High-resolution SD-OCT represents a valuable tool that can be employed as an in vivo diagnostic modality, as well as in the initial extent assessment and for delineating tumor recurrences following primary curative treatment.