ESCRS - P195 - THE BEHAVIOR OF CHORD MU (Μ) AND CHORD ALPHA (Α) LENGTH IN FUCHS ENDOTHELIAL CORNEAL DYSTROPHY AFTER DESCEMET MEMBRANE ENDOTHELIAL KERATOPLASTY (DMEK) SURGERY

THE BEHAVIOR OF CHORD MU (Μ) AND CHORD ALPHA (Α) LENGTH IN FUCHS ENDOTHELIAL CORNEAL DYSTROPHY AFTER DESCEMET MEMBRANE ENDOTHELIAL KERATOPLASTY (DMEK) SURGERY

Published 2022 - 26th ESCRS Winter Meeting

Reference: P195 | Type: Abstracts | DOI: 10.82333/jm32-8371

Authors: Carlos Rocha-De-Lossada* 1 , José-María Sánchez-González 2 , Davide Borroni 3 , Josep Torras-Sanvicens 4 , Marina Rodríguez-Calvo-de-Mora 5 , Vito Romano 6 , Jorge Peraza-Nieves 4

1Department of Ophthalmology, Cornea and Refractive Surgery,Qvision, Vithas Almería, Spain & Hospital Virgen de las Nieves, Granada, Spain,Malaga,Spain, 2Department of Physics of Condensed, Optics Area., University of Seville, Seville, Spain,Seville,Spain, 3Ophthalmology,Fondazione Banca Degli Occhi Del Veneto Onlus,Milano,Italy, 4Ophthalmology,Hospital Clinic of Barcelona,Barcelona,Spain, 5Ophthalmology,Qvision Vithas Almeria & Hospital Regional Universitario de Malaga,Malaga,Spain, 6Ophthalmology,Royal Liverpool University Hospital,Liverpool,United Kingdom

Purpose

To evaluate chord mu and alpha length in patients with Fuchs endothelial corneal dystrophy (FECD) and its changes following Descemet membrane endothelial keratoplasty (DMEK). 

Setting

Hospital Clinic of Barcelona, Spain. Department of Cornea and Anterior Segment

Methods

In this retrospective study, all DMEK surgeries performed at the Hospital Clinic of Barcelona in patients suffering from FECD between March 2017 to March 2019 by the same surgeon with at least 12 months follow-up were included. All patients were pseudophakic. Data prior to surgery, and at 1, 3 and 12 months postoperative were collected. Patients with previous corneal surgery, iris defects different from YAG-iridotomy and intra-/post-operative complications were excluded. Scheimpflug Tomography was carried out in order to calculate chord mu and chord alpha lengths prior to surgery and at 3 and 12 months postoperative by the same Ophthalmologist. All scans was previously done by the same optometrist. Data was analyzed with SPSS statistics software (version 26.0 for Windows; SPSS Inc, Chicago, IL, USA). Accepting an alpha risk of 0.05 and beta risk of 0.2 in a two-sided test, 25 subjects are necessary to recognize as statistically significance a difference greater than or equal to 0.05. The standard deviation is assumed to be 0.15. It has been anticipated a drop-out rate of 10%.

 

Results

This study included 27 eyes from 27 patients. Significant changes in chord mu were observed within the first three months (from 0.47 ± 0.32 to 0.29 ± 0.21 mm, p<0.01) and remained stable 12-months postoperative (0.30 ± 0.21 mm, p > 0.05). However, chord alpha remained stable throughout the 12-months post-surgery (from 0.53 ± 0.19 to 0.49 ± 0.14 mm, p > 0.05). In addition the distance from corneal apex to pupil center did not suffer any changes, from 0.35 ± 0.24 mm to 0.34 ± 0.20 mm (p=0.52) between preoperative and twelve-months postoperative after DMEK

Conclusion

Chord mu decreased in the first month after DMEK and remained stable with a minimal variation, especially between the third and twelfth month. Furthermore, chord alpha remained unchanged after surgery and during the entire follow-up. Here we describe the behavior of these variables after DMEK surgery. These findings may be necessary to consider in patients planning for MIOL implantation after combined with DMEK surgery.