ESCRS - P150 - HEIDELBERG ANTERION SWEPT-SOURCE OCT CORNEAL EPITHELIAL THICKNESS MAPPING: REPEATABILITY AND AGREEMENT WITH OPTOVUE AVANTI

HEIDELBERG ANTERION SWEPT-SOURCE OCT CORNEAL EPITHELIAL THICKNESS MAPPING: REPEATABILITY AND AGREEMENT WITH OPTOVUE AVANTI

Published 2022 - 26th ESCRS Winter Meeting

Reference: P150 | Type: Abstracts | DOI: 10.82333/hrr1-1k70

Authors: YUE FENG* 1 , ALEKSANDAR STOJANOVIC 2

1Institute of Community Medicine,The Arctic University of Norway,Tromsø,Norway, 2Institute of Clinical Medicine,The Arctic University of Norway,Tromsø,Norway

Purpose

To assess the repeatability of Corneal Epithelial Thickness Mapping (ETM) in virgin, post-laser refractive surgery (PLRS), and keratoconic eyes (KC), using a novel swept-source (SS) optical coherence tomographer (OCT), and to determine the agreement of the measurements with a validated spectral-domain (SD) OCT.

Setting

The Eye-department of the University Hospital North Norway, Tromsø, Norway

Øyelegesenteret Eye Clinic, Tromsø, Norway

Methods

Analysis of 90 virgin, 46 PLRS and 122 KC eyes was performed. Three consecutive measurements of each eye were acquired with the Anterion SS-OCT and Avanti SD-OCT devices, and averages of the ETMs were calculated in the central 2 mm zone as well as in the 2-5 mm and 5-7 mm diameter rings. The repeatability was analyzed using pooled within-subject standard deviation (Sw). The agreement was assessed by Bland-Altman analysis and paired t-tests.

Results

Repeatability of Anterion ETM measurements were: Sw: 0.60 - 1.36 μm. Anterion and Avanti 95% limits of agreement (LoA) were: 0.826 - 8.297. All the values of the thickness measurements with Anterion were lower than Avanti’s, with the mean differences: 4.06 ± 1.81 μm, 3.26 ± 2.52 μm and 3.68 ± 2.51 μm in virgin, PLRS and KC eyes, respectively (p < 0.001 for all).

Conclusion

The repeatability of the Anterion’s ETM was very high. The general agreement between the Anterion and Avanti was very good, however the epithelium measured by the Anterion was always thinner than Avanti, making their interchangeable use unsuitable without corrections.