AMLODIPINE AS A NEW RISK FACTOR FOR INTRAOPERATIVE FLOPPY IRIS SYNDROME

The purpose of our study is to demonstrate that Amlodipine is a possible risk factor of IFIS for patients undergoing cataract phacoemulsification.

We have noticed a high rate of intra operative  floppy iris sydrome among patients taking Amlodipine as a high blood pressure medication. We decided to conduct a unvirariate study called IFISAM to compare the incidence of IFIS between two comparative goupes ( age , gender , same inclusion criterias and same exclusion criterias ) with the variant being Amlodipine as HBP medication.

Included in IFISAM study, were 200 eyes of 200 patients who underwent cataract phacoemulsification with implantation of intraocular lens (IOL) in the posterior chamber. The following patient’s information was collected: age ( fixated range between 50 and 65 yo ), gender, high blood pressure and its medication, diabetes millitus, pupillary diameter before and after dilatation, glaucoma and pseudo exfoliation syndrome. Were excluded all patients under alpha-blockers, finasteride or benzodiazepine, as well as patients with pseudo-exfoliation syndrome. Patients were classified as IFIS or non-IFIS after surgery. Univariate logistic regression analysis were performed.

The overall incidence of IFIS was of 12% (24/200 eyes). Among the patients classified IFIS after the surgery,  14 were under amlodipine as high blood pressure medication (58%).

Our study came to the prime conclusion that amlodipine might be a valid risk factor for developing IFIS .