ISOPURE: FUNCTIONAL OUTCOMES AND PATIENT SATISFACTION AFTER BILATERAL IMPLANTATION OF A PREMIUM MONOFOCAL INTRAOCULAR LENS.

ISOPURE (PhysIOL, Liège, Belgium) is an enhanced posterior chamber, premium monofocal intraocular lens (IOL) based on the patented ISOFOCAL concept. The optic displays polynomial complex surface design parameters to extend the Depth of Focus compared to standard monofocal IOLs. The lens is purely refractive and fine-tuned for each dioptric power. The purpose of this retrospective study is to investigate functional clinical outcomes and patient satisfaction after bilateral implantation of ISOPURE IOL during cataract surgery.

23 patients (46 eyes) were retrospectively evaluated at least 4 months after cataract surgery and binocular ISOPURE implantation. Emmetropia was targeted in one eye and -0.5-0.75 diopter (D) myopia in the contralateral. Follow-up examinations included: uncorrected and distance-corrected Visual Acuity (UDVA and CDVA), intermediate (UIVA and DCIVA) at 80 and 66 cm, and near (UNVA and DCNVA) at 40 cm. Binocular defocus curves were recorded between -2.5D and +1.5D in 0.5D steps. Binocular contrast sensitivity (CS) was evaluated under mesopic and photopic conditions. Post-operative patient satisfaction and spectacle independence were evaluated with Quality of Life (NEI RQL-42) and PRSIQ Questionnaires.

Mean patients age was 68 years old and mean follow up after surgery was 10.2 months. Mean Log MAR binocular Uncorrected Visual Acuity were as follows: UDVA 0±0.07, UCIVA (80 cm) 0.02±0.08, UCIVA (66 cm) 0.06±0.08 and UNVA (40 cm) 0.2±0.13. Binocular defocus curves confirmed a broad profile and CS curves were within the normal range for the age group. In patients implanted bilaterally, subjective questionnaires indicate high spectacle independence at far and intermediate distances (91%) and no adverse dysphotopic phenomena (92%).

Clinical results show this enhanced monofocal IOL allows patients to experience high-quality vision at far distances and improved useful vision at intermediate distances without inducing undesirable photic effects. A high level of patient satisfaction and a very reasonable spectacle independence outcomes were also obtained. Compared to conventional monofocal lenses, this Premium monofocal IOL shows an improvement in the uncorrected intermediate vision outcomes so often required for many daily tasks.