OPTIC DISC AND MACULAR MICROVASCULAR CHANGES IN ANISOMETROPIC AMBLYOPIA BEFORE AND AFTER TREATMENT
Published 2026 - 30th ESCRS Winter Meeting
Reference: PO068 | Type: Free Paper | DOI: 10.82333/8y0g-rd06
Authors: Chang Won Park* 1 , Jae Pil Jeong 2 , Ji Won Park 3 , Ying Jun Li 4
1Department of Optometry,Baekseok Culture University,Cheonan,Korea, Republic Of, 2Department of Art & Technology ,Chung-Ang University,Anseong,Korea, Republic Of, 3Laser and Phototherapy Department,Bbeauty365Clinic,Chuncheon,Korea, Republic Of, 4Department of Ophthalmology ,FuyangPeople’s Hospital of Anhui Medical University,Anhui,China
Purpose
Assessment of Optic Disc and Macular Microvascular Alterations in Pediatric Anisometropic Amblyopia Before
and After Treatment.
Setting
Sixty males and 31 females from Fuyang People’s Hospital were selected between January 2022 and December The study included children aged 5 to 12 years with anisometropic amblyopia, defined by a ≥2-line difference in
BCVA or BCVA worse than 20/30. The control group consisted of age- and sex-matched children with normal BCVA. Exclusion criteria included ocular trauma, serious eye diseases, systemic conditions affecting retinal circulation, or
inability to cooperate.
Methods
A total of 40 children, aged 6 to 12 years, with unilateral anisometropic amblyopia were randomly selected from the ophthalmology clinic at Fuyang People’s Hospital. Additionally, 40 age-matched children without amblyopia were
selected as a control group. The right eye was uniformly selected for the control group, with a minimum follow-up duration of 6 months. Optical coherence tomography angiography (OCTA) was employed to assess various parameters, including
the vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in the macula, optic disc vascular density (VD), foveal avascular zone (FAZ) area, macular thickness, and retinal nerve fiber layer thickness
(RNFLT).
Results
Before treatment, vascular density in the optic disc, macular superficial capillary plexus (SCP), and deep capillary plexus (DCP) was significantly lower in the amblyopic group compared to the fellow eyes and control group (P <
0.05). After treatment, no significant differences were observed between the amblyopic eyes, fellow eyes, and control group (P > 0.05). Negative correlations were found between changes in best corrected visual acuity (BCVA) and vessel
density alterations in the optic disc, macular SCP, and DCP (P < 0.05), except in specific regions of the optic disc and macular SCP/DCP (P > 0.05).
Conclusion
In children with anisometropic amblyopia, optical coherence tomography angiography (OCTA) reveals reduced vessel density in both the macula and optic disc. Following amblyopia treatment, these vascular densities tend to
partially normalize.