CORRECTED AXIAL LENGTH AND CHOROIDAL THICKNESS: A CORRELATION ANALYSIS FOR SCIENTIFIC PURPOSES
Published 2026 - 30th ESCRS Winter Meeting
Reference: FP07.09 | Type: Free Paper | DOI: 10.82333/ckxm-xy33
Authors: Ferdinando Cione* 1 , Marco Gioia 2 , Martina De Luca 3 , Benedetta Cioffi 4 , Matteo Savo 4 , Maddalena De Bernardo 1
1Ophthalmological Unit, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana,University of Salerno,Salerno,Italy;AOU San Giovanni di Dio e Ruggi D'Aragona,Salerno,Italy, 2Ophthalmological Unit, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana,University of Salerno,Salerno,Italy;Ophthalmological Unit,PO Maria SS Addolorata,Eboli,Italy, 3Ophthalmological Unit,Pellegrini Hospital,Naples,Italy, 4Ophthalmological Unit, Department of Medicine, Surgery and Dentistry, Scuola Medica Salernitana,University of Salerno,Salerno,Italy
Purpose
Choroidal thickness (ChT) is an important parameter in assessing ocular and systemic diseases and it has been shown to be axial length (AL) related. Due to inaccuracy of optical biometry in measuring AL, this study aimed to determine whether the established inverse correlation between AL and ChT persists when using a corrected AL (ALc).
Setting
University Eye Unit, Department of Medicine and Surgery, University of Salerno, Italy.
Methods
All subjects underwent a complete eye examination, including spectral domain optical coherence tomography (OCT) with enhanced depth image (EDI) mode and AL measurement with IOLMaster, a partial coherence interferometry (PCI) based biometer. After a normality check of the data, the Student T-test was used for pair-wise comparisons of AL and ALc. Correlations between ChT with AL and ALc were investigated using the Pearson correlation coefficient and the Pearson coefficient of determination. Pearson’s analysis with bootstrap was also performed in additional evaluation according to eye-side subgroups. P values <0.05 were considered statistically significant.
Results
One hundred eyes of 50 healthy patients were evaluated. The mean AL was 24.36±1.23mm and mean ALc was 24.25±1.22mm. The mean nasal ChT, subfoveal ChT, and temporal ChT were, respectively, 250.57±93.93μm, 307.18±101.66μm, and 313.72±88.86μm. A significant negative linear correlation was found between ChT and both AL and ALc (all r<−0.500, all p<0.050). The negative linear correlation was stronger between nasal ChT and both AL and ALc (all r=−0.581).
Conclusion
Our results confirm a statistically significant correlation between ALc and ChT. Therefore, both AL and ChT changes should be evaluated according to ALc, changing the cut-off values to avoid the systematic errors in optical biometry. Moreover, we recommend stratifying population according to ALc because linear correlation is still present.