Association Between Metabolic Syndrome And Cataract: A Meta-Analysis Of Real-World Database
Published 2025 - 43rd Congress of the ESCRS
Reference: PP27.06 | Type: Poster | DOI: 10.82333/zd8h-8w77
Authors: Pawaris Tirakunwichcha* 1 , Patavee Pajareya 1 , Somkiat Phutinart 1 , Chanissara Winson 1 , Noppachai Siranart 1
1Faculty of Medicine,King Chulalongkorn Memorial Hospital,Bangkok,Thailand
Purpose
Cataract is the leading cause of blindness worldwide. Obesity, a key component of metabolic syndrome (MetS), may represent a modifiable risk factor for cataract. However, the evidence regarding the association between MetS or its components and cataract remains controversial. Therefore, our meta-analysis aims to clarify the relationship between MetS or its components with cataract.
Setting
The inclusion criteria of the included studies are (I) Studies reporting a head-to-head comparison between cataract patients who have MetS and its components and those without. (II) Patients aged >18 years. The exclusion criteria are (I) Studies reporting eye diseases other than cataract.
Methods
Search was conducted up until February 2024 via MEDLINE, EMBASE, and Cochrane database. Primary endpoint is the association between MetS or its components including body mass index (BMI), diabetes mellitus (DM), hypertension (HT), and dyslipidemia (DLP), and cataract. Secondary endpoints are the association between levels of blood pressure, blood sugar, and lipid profiles and cataract.
Results
A total of 27 studies were included with a total of 1,010,014 patients. The prevalence of cataract was 13.3%. MetS was significantly associated with cataract with an OR of 1.60(95%CI:1.44-1.77,I2=93%). Among MetS components, patients with overweight and underlying DM, HT, and DLP were associated with cataract with an OR of 1.44(95%CI:1.32-1.57,I2=78%), 1.77(95%CI:1.69-1.85,I2=51%), 1.23(95%CI:1.19-1.28,I2=62%), and 1.38(95%CI:1.30-1.46,I2=0%). Among metabolic parameters, higher TC, higher TG, lower HDL-C, and higher LDL-C were associated with cataract with ORs of 1.25(95%CI:1.04-1.49,I2=48%), 1.05(95%CI:1.04-1.06,I2=68%), 1.07(95%CI:1.01-1.13,I2=0%), 1.30(95%CI:1.10-1.53,I2=71%) respectively.
Conclusions
MetS, obesity, DM, HT, and DLP are associated with cataract. Prompt diagnosis and treatment of MetS are crucial to prevent cataract formation. Early screening test may be utilized as a prevention strategy in these patient population.