Two-Year Results Of A Prospective Randomized Control Trial Measuring Posterior Capsular Opacification Rates And Visual Outcomes Following Insertion Of Two Monofocal,Intraocular Lenses: The Hydrophobic Rayone 800C And The Hydrophilic Rayone 600C

To compare posterior capsular opacification (PCO), Nd: YAG laser capsulotomy rates, visual outcomes, and patient satisfaction of patients following insertion of either the hydrophilic RayOne 600C monofocal intraocular lens (IOL) or the hydrophobic RayOne 800C monofocal IOL. Both IOLs are manufactured by the same manufacturer (Rayner Ltd, Worthing, UK) and are structurally similar, with square edges and comparable optic and haptic designs.

University Hospital, London, United Kingdom.

Patients with visually symptomatic cataract were randomised to receive one of the two IOLs during micro-incisional phacoemulsification cataract surgery (CS). Thirty-nine eyes of 39 patients received the RayOne 600C IOL (HPL group) and 46 eyes of 46 patients received the RayOne 800C IOL (HPB group). Patients were seen at baselin, at 1 month (1M), 6M, 12M, and 24M post-CS. Primary outcome measures included the development of visually significant PCO requiring Nd: YAG laser capsulotomy and the mean percentage of PCO within the central 4 millimeters (mm) of the IOL as measured from digital photography of the lens capsules. Secondary outcome measures including visual outcomes, patient reported outcome measures (CATPROM-5), and adverse events.

Seventy-two patients attended 24M follow-up (37 in HPL group, 35 in HPB group). At 24M, there were statistically significant improvements in UDVA, BDVA and CATPROM-5 scores compared to baseline in the HPL group (all p<0.0001), and in the HPB group (all p<0.0001). At 24 months, 2 patients in the HPL group and 6 patients in the HPB group required Nd: YAG laser capsulotomy for visually significant PCO (p=0.14). There were no statistically significant difference in visual outcomes, CATPROM-5 scores, or adverse events between the two groups. At 12M there were no differences in mean percentage areas of PCO between the two groups.

Our results indicate there are no statistically significant differences in post-operative visual outcomes and visually significant PCO between the groups. We will present further 24M data comparing the mean percentage area of PCO within the central 4mm of the IOL.