The Role Of Substance P In Corneal Homeostasis
Published 2025 - 43rd Congress of the ESCRS
Reference: PO995 | Type: Poster | DOI: 10.82333/vn1v-m529
Authors: Irmina Maria Jastrzębska-Miazga* 1 , Adrian Smedowski 2 , Bartosz Machna 1 , Dorota Wygledowska-Promienska 3 , Aleksandra Gorska 4
1Department of Ophthalmology, Kornel Gibiński University Clinical Center, Medical University of Silesia, Katowice, Poland,Katowice,Poland, 2Department of Ophthalmology, Kornel Gibiński University Clinical Center, Medical University of Silesia, Katowice, Poland,Katowice,Poland;Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland,Katowice,Poland;3GlaucoTech Co,Katowice,Poland, 3Department of Ophthalmology, Kornel Gibiński University Clinical Center, Medical University of Silesia, Katowice, Poland,Katowice,Poland;Department of Ophthalmology, Faculty of Medical Sciences in Katowice, Medical University of Silesia, Katowice, Poland,Katowice,Poland, 41Department of Ophthalmology, Kornel Gibiński University Clinical Center, Medical University of Silesia, Katowice, Poland,Katowice,Poland
Purpose
The purpose of this article is to explore the multifaceted role of Substance P (SP) in maintaining corneal homeostasis, with a focus on its involvement in epithelial integrity, wound healing, immune response, and pain modulation. Additionally, the review highlights the therapeutic potential of SP in ocular surface diseases and discusses the challenges associated with its dichotomous nature in regulating both pro-inflammatory and healing processes.
Setting
A literature review was conducted on the role of substance P in corneal homeostasis, including in vitro, in vivo, and clinical studies. The mechanisms of SP action through its receptors (NK1R, NK2R, NK3R) and its impact on inflammatory processes, angiogenesis, and wound healing were analyzed.
Methods
A literature review was conducted on the role of substance P in corneal homeostasis, including in vitro, in vivo, and clinical studies. The mechanisms of SP action through its receptors (NK1R, NK2R, NK3R) and its impact on inflammatory processes, angiogenesis, and wound healing were analyzed.
Results
Substance P is essential for maintaining corneal epithelial integrity, promoting keratocyte migration and epithelial cell proliferation. At the same time, SP can amplify the inflammatory response, leading to neovascularization and other corneal pathologies. Studies have shown that SP influences the production of cytokines and chemokines, such as IL-8, which attracts neutrophils and other immune cells to the site of inflammation. Additionally, SP plays a role in pain regulation, acting both as a pro-nociceptive and anti-nociceptive mediator.
Conclusions
Substance P has therapeutic potential in the treatment of ocular surface diseases, such as neurotrophic keratitis and dry eye syndrome. However, its dual nature—both pro-inflammatory and pro-regenerative—poses a challenge for developing effective therapies. Further research is needed to better understand the mechanisms of SP and its receptors, which may lead to the development of new therapeutic strategies.