Longitudinal Study Of Changes In Retinal Curvature And Its Relationship With Myopia Shift In Chinese Children
Published 2025 - 43rd Congress of the ESCRS
Reference: PO785 | Type: Free paper | DOI: 10.82333/eyyz-h234
Authors: Emmanouil Xylouris* 1 , Santaro Noguchi 2 , Ioannis Pallikaris 3 , Harilaos Ginis 4 , Aristofanis Pallikaris 4
1University of Crete, Medical School,Laboratory of Vision and Optics,Heraklion,Greece;Ophthalmology,Venizeleion General Hospital of Heraklion,Heraklion,Greece, 2ASUKA eye clinic,Sendai,Japan, 3Laboratory of Vision and Optics,Heraklion,Greece, 4University of Crete, Medical School,Laboratory of Vision and Optics,Heraklion,Greece
Purpose
To investigate longitudinal changes in retinal curvature (RC) among Chinese children and its relationship with myopia progression.
Setting
The study protocol was authorized by the Institutional Review Board of Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine and adhered to the tenets of the Declaration of Helsinki. The participants in this prospective, longitudinal study had been recruited between February 2021 and February 2022.Comprehensive eye examinations utilized advanced imaging techniques, including swept-source optical coherence tomography (SS-OCT).
Methods
This 12-month longitudinal study included children aged 6–16, divided into groups based on changes in spherical equivalent refraction (SER) over 1 year: myopic shift group and non-myopic shift group. Comprehensive examinations including swept-source optical coherence tomography were performed in each visit. RC was assessed using a customized 3D reconstruction algorithm. The central, temporal, nasal, superior, and inferior quadrates were further divided into nine regions and calculated the average curvature for each. The retinal surface asymmetry index (R-SAI) was calculated to describe regional differences in RC. Statistical analyses were performed to explore correlations between RC changes and myopia progression.
Results
Significant increases in central RC were observed in the myopic shift group, particularly in the 0-6mm-diameter central retinal region. Regional analysis showed that significant changes in curvature were observed in the myopic shift group particularly in the 0-3mm central circle (C0), temporal quadrate of 3-6mm (T1) and 6-9mm ring (T2) and inferior quadrate of 3-6mm ring (I1), with the most predominant increase in T1 region. Negative correlation was found between baseline nasal-temporal R-SAI and myopic shift after controlling confounders. Age, AL elongation and smaller baseline curvature were associated with larger RC changes in the central macular region.
Conclusions
RC changes are closely linked to myopia shift. Longitudinal monitoring of RC can serve as a valuable quantitative measure for assessing morphological changes associated with myopia shift in children.