Quantum Molecular Resonance And Mesenchymal Secretome: A Novel Therapeutic Approach For Oxidative Stress And Inflammation In Ocular Surface And Retinal Diseases
Published 2025 - 43rd Congress of the ESCRS
Reference: PO634 | Type: Free paper | DOI: 10.82333/1fta-4b74
Authors: Chitra Ramamurthy* 1 , Tamilarasi Subramaniam 2 , Zunaitha Fathima T 2
1Glaucoma,The Eye Foundation,Coimbatore,India, 2Ophthalmology,The Eye Foundation,Coimbatore,India
Purpose
Ocular Surface Disease (OSD) and Inherited Retinal Dystrophies (IRDs) share common pathological mechanisms, including oxidative stress, inflammation, and cellular degeneration. This study aims to identify novel transcriptomic biomarkers associated with oxidative stress in ocular tissues, exploring the therapeutic potential of Quantum Molecular Resonance (QMR®) and mesenchymal secretome to counteract damage and promote cellular regeneration. The results could contribute to the development of new strategies for ocular surface disorders, particularly in conditions characterized by chronic oxidative and inflammatory stress.
Setting
Department of Biomedical, Odontoiatric, and Morphofunctional Imaging Sciences, University of Messina, in collaboration with Resono Ophthalmic S.r.l.
Methods
Human Retinal Pigment Epithelium (RPE) cells, sharing functional similarities with corneal and conjunctival epithelial cells, were cultured and exposed to oxidative stress via tert-Butyl hydroperoxide (tBHP) to model chronic ocular inflammation. Cells were assigned to 16 groups and treated with QMR®, a non-invasive technology modulating cellular responses; mesenchymal secretome, with anti-inflammatory and regenerative properties; or a combined QMR® + secretome therapy. Samples were collected at 24h, 48h, and 72h for RNA-Sequencing. Differential gene expression and pathway analysis identified molecular signatures of oxidative stress, inflammation, and repair. Functional validation included qPCR, apoptosis assays, and viability tests.
Results
Our preliminary findings reveal a strong link between oxidative stress-induced transcriptomic changes in RPE cells and molecular pathways in OSD, suggesting shared degenerative mechanisms. This reinforces the role of oxidative and inflammatory processes in both retinal and ocular surface diseases. QMR® and mesenchymal secretome treatments show promising protective and regenerative effects, mitigating oxidative damage, reducing inflammation, and enhancing cellular resilience. These findings support their potential therapeutic application beyond IRDs, extending to ocular surface diseases like dry eye syndrome, limbal stem cell deficiency, and neurotrophic keratopathy, paving the way for novel treatment strategies.
Conclusions
Our findings could redefine therapeutic strategies for ocular surface diseases by integrating advanced transcriptomics and regenerative technologies. The cross-link between oxidative stress in retinal and corneal epithelial cells suggests that targeted interventions such as QMR® therapy and mesenchymal secretome could provide novel, non-invasive solutions for managing inflammatory ocular disorders.
Financial Disclosure
This research is supported by Resono Ophthalmic S.r.l., with no conflicts of interest to disclose.