A Systematic Review Of Atmospheric Plasma Applications In Ophthalmology

The primary outcomes of interest in this review are the efficacy of Atmospheric Plasma (AP) in reducing microbial load, promoting corneal wound healing, and improving surgical outcomes. Secondary outcomes include safety assessments, such as adverse events, tissue damage, and inflammation. Studies conducted worldwide within the last 10 years are included in this review to provide a comprehensive and up-to-date understanding of AP applications in ophthalmology.The purpose of this study is  systematically review the therapeutic applications of (AP) in ophthalmology, focusing on its benefits, mechanisms of action, safety, and potential for future use.

This systematic review focuses on clinical studies, in vitro experiments, and preclinical research investigating the applications of  atmospheric plasma (AP) in ophthalmology. The studies included in this review examine various aspects of AP , including its antimicrobial properties, effects on corneal wound healing, and potential applications in ocular surgeries.

A comprehensive literature search was conducted using multiple databases (e.g., PubMed, Web of Science) to identify relevant studies on AP applications in ophthalmology. Inclusion criteria encompassed in vitro, animal, and clinical studies assessing AP's effects on ocular health and surgical precision. Data extraction and quality assessment were performed following PRISMA guidelines

AP showed efficacy in promoting corneal wound healing, reducing scarring, and exhibiting antimicrobial properties, potentially preventing postsurgical infections. AP also demonstrated regenerative capabilities, improving cell proliferation, migration, and adhesion, while enhancing drug delivery and minimizing scar formation. Underlying mechanisms involve reactive species generation and immune response modulation. The safety of AP was validated in ocular applications, with minimal inflammatory responses and successful integration with ocular tissues.

AP has significant potential in ophthalmology and regenerative therapies, necessitating further clinical trials to refine treatment parameters and evaluate long-term outcomes. This systematic review highlights AP's role in advancing medical practices for ocular health, surgical precision, and infection management.