ESCRS - PO586 - Prospective Open Label Randomized Controlled Clinical Study Evaluating The Efficacy Of Perceptual Learning In Improving Vision Among Patients With Keratoconus

Prospective Open Label Randomized Controlled Clinical Study Evaluating The Efficacy Of Perceptual Learning In Improving Vision Among Patients With Keratoconus

Published 2025 - 43rd Congress of the ESCRS

Reference: PO586 | Type: Free paper | DOI: 10.82333/79tv-sp71

Authors: Biljana Kostovska* 1 , Sara Blazhevska 2 , Martina Sofronijevikj 3 , Era Tateshi 4 , Ljuben Angjelovski 3 , Irina Bogdanova 5

1Sistina Ophthalmology, Promedika,Skopje,North Macedonia;Faculty of Medical Sciences, Goce Delcev University,Stip,North Macedonia, 2University Eye Hospital “Svjetlost”,Zagreb,Croatia, 3Sistina Ophthalmology, Promedika,Skopje,North Macedonia, 4City General Hospital “8th September",Skopje,North Macedonia, 5University Eye Clinic “Mother Teresa” ,Skopje,North Macedonia

Purpose

To examine the use of perceptual learning in improving vision of patients with Keratoconus

Setting

Pprospective randomized controlled open label study

Methods

This is an ongoing prospective randomized controlled open label study performed at Shamir Medical center starting from 2023. The study comprises 35 patients in the treatment group and 10 patients in the control group. Included were patients between the ages of 14-55 years with stable keratoconus in the past 12 months in terms of corneal tomography, refraction and best corrected visual acuity (BCVA). The treatment group underwent Perceptual Learning Therapy for four months. The control group were followed without treatment. BCVA and contrast sensitivity were assessed.

Results

 In our preliminary results, 10 patients were included in the treatment group and 2 patients in the control group. Mean patients age was 33.3±7.4 years. In the treatment group, BCVA improved by 0.24±0.13 logMAR, compared to a change of 0.02 logMAR in the control group (p<0.01). An average improvement of 2.4 lines was seen in the ETDRS chart following treatment. Contrast sensitivity improved by 11116.82±187.2% in the treatment group (p=0.09). 

Conclusions

In this prospective randomized controlled open label study, visual perceptual learning resulted in significant improvement in distance visual acuity, with a corresponding trend toward improvement in contrast sensitivity, among patients with stable keratoconus.