Quality Of Life In Patients With And Without Keratoconus In Thammasat University Hospital: A Comparative Analysis

Keratoconus is a progressive corneal ectatic disease that significantly impacts visual function and quality of life (QoL) in affected individuals. This primary objective of this study aimed to evaluate the QoL of keratoconus patients in Thammasat University Hospital and compare it with a control group. The secondary objective was a subgroup analysis aimed to compare the QoL between keratoconus patients who underwent collagen cross-linking (CXL) with those who received supportive treatment.

Thammasat University Hospital, Pathumthani Province, Thailand

Keratoconus patients were recruited from Thammasat University Hospital’s by random sampling. Control patients were recruited by consent at the General Practice Outpatient Department. The Thai version of the National Eye Institute of Visual Functioning Questionnaire (T-NEI-VFQ-25) was used to assess quality of life in both groups. We categorised 25 items of the questionnaire into seven categories related to quality of life. For every response, worded choices of answers was converted into integer scores with 5 associated with the best possible quality of life and 1 being least favourable quality of life. Two-sample two-tailed t-test was used to determine statistical significance at alpha = 0.05.

The results showed that all QoL domains were negatively impacted in keratoconus patients, with the most significant compromise observed in mental health (mean score = 3.961). The least disturbed component was social aspects (mean score = 4.597). The domain with the greatest difference between kerataconus and control was social aspects (p ≤0.05). Subgroup analysis revealed no statistically significant difference between the two groups of keratoconus patients regarding QoL, though the CXL group reported lower scores in mental health (mean score of 4.175 versus 3.733, p ≤0.05). Those who underwent CXL had better scores in ocular symptoms, activities of daily living and transportation.

These findings suggest that keratoconus affects various aspects of QoL, with mental health being a key concern. The study underscores the importance of integrating QoL assessments into clinical management to tailor treatments, including the consideration of mental health in treatment plans. Further research is needed to explore the long-term effects of collagen cross-linking and other surgical treatments on QoL in keratoconus patients.