Six-Years Experience After Implantation Of The Artificial Endothelial Layer Implant
Published 2025 - 43rd Congress of the ESCRS
Reference: PO536 | Type: Free paper | DOI: 10.82333/0zjb-d489
Authors: Pablo Artal* 1 , Jose María Marín 2 , Encarna Alcón 2 , Consuelo Robles 3 , Lucía Hervella 3 , Elsa Albero 3 , Eloy Villegas 1
1Laboratorio de Óptica,Universidad de Murcia,Murcia,Spain, 2Oftalvist,Murcia,Spain, 3Voptica SL,Murcia,Spain
Purpose
To report the long-term experience of the synthetic endothelial layer for treatment of chronic corneal edema.
Setting
Prospective, observational, single-center case series in a tertiary hospital in Germany.
Methods
This retrospective study analyzed patients who received the artificial endothelial implant (EndoArt, EyeYon Medical, Israel) up to 6 years ago. Intraoperatively, air-gas bubble and in some cases, corneal sutures were used to secure the graft on the posterior stroma. Primary endpoint was change in central corneal thickness (CCT).
Results
Mean follow-up was 42 months (range: 31-72 months). In all patients, the EndoArt led to significant reduction of CCT from 810.0±113.4 µm preoperatively to 511.7±31.0 µm at 6-months postoperatively (p=0.037). In patients 1 and 3, the central cornea remained clear and CCT stable at 3 and 6-years postoperatively, respectively. In patient 2, significant stromal scarring ultimately led to EndoArt explantation and penetrating keratoplasty at 31-months postoperatively.
Conclusions
Our study shows that the artificial lamella can effectively reduce CCT in eyes with chronic corneal edema. Patients with significant stromal scarring may benefit less from the efficacy of the artificial implant.