Scheimpflug Tomography Changes In Patients With Keratoconus After Collagen Cross-Linking – One-Year Follow-Up
Published 2025 - 43rd Congress of the ESCRS
Reference: PO489 | Type: Free paper | DOI: 10.82333/kxpj-t704
Authors: Biljana Kuzmanovic Elabjer 1 , Tea FRKANEC* 2 , Iva Cubela 2 , Mladen Busic 1 , Mirjana Bjelos 1
1University Eye Department,University Hospital "Sveti Duh",Zagreb,Croatia;Faculty of Medicine,University Josip Juraj Strossmayer,Osijek,Croatia;Faculty of Dental Medicine and Health,University Josip Juraj Strossmayer,Osijek,Croatia, 2University Eye Department,University Hospital "Sveti Duh",Zagreb,Croatia
Purpose
To evaluate scheimpflug tomography changes in patients with keratoconus before and one year after collagen cross-linking (CXL).
Setting
A retrospective study was conducted on 46 patients of both genders who underwent CXL procedures at the University Eye Department, University Hospital „Sveti Duh“ Zagreb, Croatia, between January 2023 and December 2023. In all cases, an accelerated epi-off CXL protocol was used with the application of a 9-mW/cm² lamp (UV-XTM 2000; IROC Innocross) UVA irradiation for 10 minutes after 30 minutes of iso-osmolar riboflavin administration.
Methods
Data were collected preoperatively and one year after CXL. Tomography was performed using the rotating Scheimpflug imaging Pentacam HR (Oculus, Germany). Maximum Keratometry (Kmax), mean Keratometry (K) front and back, Central Corneal Thickness (CCT), Index Surface Variance (ISV), Index Vertical Asymmetry (IVA), Keratoconus Index (KI), Central Keratoconus Index (CKI), Index Height Asymmetry (IHA), Index Height Decentration (IHD), Minimum Curvature Radius (Rmin), Belin/Ambrosio Deviation Display (BAD_D), and Progression Index Average (PIAVG) were analyzed.
Results
A Wilcoxon Signed-Rank Test indicated that Kmax, ISV, IVA, IHD, and Rmin were significantly different before and one year after the CXL (Z= -3,584, P=<0,001, Z=-3,829, P=<0,001, Z=-3,778, P=<0,001, Z=-4,109, P=<0,001, Z=3,565, P=<0,001). The effect size in all parameters was large (r=-0,565, r=-0,557, r=-0,606, r=0,526). There were no significant differences in other parameters.
Conclusions
Our findings demonstrated a significant reduction in Kmax, ISV, IVA, and IHD one year after CXL, suggesting a decrease in keratoconus severity. Additionally, the statistically significant increase in Rmin indicates corneal flattening. These results suggest that within the first year post-procedure, there was no significant progression of keratoconus, indicating that disease advancement was successfully halted during this period following CXL.