Biocompatibility Evaluation Of A New Material For Intraocular Lenses
Published 2025 - 43rd Congress of the ESCRS
Reference: PO442 | Type: Free paper | DOI: 10.82333/d7sn-p736
Authors: Mario Troisi* 1 , Salvatore Del Prete 2 , Daniela Marasco 2 , Ciro Costagliola 1 , Francesco Semeraro 3 , Vito Romano 3
1Ophthalmology Department,University of Naples Federico II,Naples,Italy, 2Biotechnology,Service Biotech srl,Naples,Italy, 3Ophthalmology Department,University of Brescia,Brescia,Italy
Purpose
To evaluate the uveal and capsular biocompatibility of a new material for intraocular lens (IOL) fabrication, the Eyedeal® (Xi'an Eyedeal Medical Technology, Inc. Ltd, Shaanxi, China), in comparison to a commercial reference IOL in a rabbit model.
Setting
Envigo CRS (Israel) Limited.
Methods
Bilateral phacoemulsification was performed in 10 rabbits; 1 eye was implanted with the test IOL, the Eyedeal®, and the other eye was implanted with the Reference IOL, the AcrySof® SA60AT (Alcon, Fort Worth, USA). Slit-lamp examinations were performed at postoperative weeks 1 and 6. The rabbits were euthanized at six weeks postoperatively, and the eyes were enucleated. After gross examination with the Miyake-Apple view, all eyes were sectioned and processed for histopathologic examination.
Results
No difference was found in the uveal and capsular biocompatibility of the study and control IOLs in the biomicroscopy, Miyake-Apple posterior view, and histopathologic examination. A trend toward lower incidence and mean group severity of Soemmerring's ring was found in the Eyedeal® IOL group.
Conclusions
The Eyedeal® IOL was found non-inferior to the Reference IOL, the AcrySof® SA60AT. Both groups demonstrated the typical, expected ocular reactions of PCO and Soemmerring's ring after IOL implantation in rabbit eyes.