Evaluation Of Optic Disc And Macular Microvascular Changes In Children With Anisometropic Amblyopia Pre- And Post-Treatment: A Comparative Study
Published 2025 - 43rd Congress of the ESCRS
Reference: PO1071 | Type: Poster | DOI: 10.82333/xz89-d447
Authors: Ying jun Li* 1 , Hyun Uk Park 2 , Jae Pil Jeong 3 , Chang Won Park 4
1Department of Ophthalmology ,FuyangPeople’s Hospital of Anhui Medical University,Anhui,China, 2Department of leisure and sports,Baekseok Culture University,Cheonan,Korea, Republic Of, 3Department of Art & Technology ,Chung-Ang University,Anseong,Korea, Republic Of, 4Department of Optometry,Baekseok Culture University,Cheonan,Korea, Republic Of
Purpose
Assessment of Optic Disc and Macular Microvascular Alterations in Pediatric Anisometropic Amblyopia Before and After Treatment.
Setting
Sixty males and 31 females from Fuyang People’s Hospital were selected between January 2022 and December 2023. The study included children aged 5 to 12 years with anisometropic amblyopia, defined by a ≥2-line difference in BCVA or BCVA worse than 20/30. The control group consisted of age- and sex-matched children with normal BCVA.
Exclusion criteria included ocular trauma, serious eye diseases, systemic conditions affecting retinal circulation, or inability to cooperate.
Methods
A total of 40 children, aged 6 to 12 years, with unilateral anisometropic amblyopia were randomly selected from the ophthalmology clinic at Fuyang People’s Hospital. Additionally, 40 age-matched children without amblyopia were selected as a control group. The right eye was uniformly selected for the control group, with a minimum follow-up duration of 6 months. Optical coherence tomography angiography (OCTA) was employed to assess various parameters, including the vessel density of the superficial capillary plexus (SCP) and deep capillary plexus (DCP) in the macula, optic disc vascular density (VD), foveal avascular zone (FAZ) area, macular thickness, and retinal nerve fiber layer thickness (RNFLT).
Results
Before treatment, vascular density in the optic disc, macular superficial capillary plexus (SCP), and deep capillary plexus (DCP) was significantly lower in the amblyopic group compared to the fellow eyes and control group (P < 0.05). After treatment, no significant differences were observed between the amblyopic eyes, fellow eyes, and control group (P > 0.05). Negative correlations were found between changes in best corrected visual acuity (BCVA) and vessel density alterations in the optic disc, macular SCP, and DCP (P < 0.05), except in specific regions of the optic disc and macular SCP/DCP (P > 0.05).
Conclusions
In children with anisometropic amblyopia, optical coherence tomography angiography (OCTA) reveals reduced vessel density in both the macula and optic disc. Following amblyopia treatment, these vascular densities tend to partially normalize.