Endoart® In Complex Anterior Segments – A Case Series

To present a series of artificial lamellar cornea, EndoArt^® (EyeYon Medical, Ness Ziona, Israel) transplantation in complex anterior segment cases.

Sussex Eye Hospital, University Hospitals Sussex NHS Foundation Trust, Brighton, United Kingdom.

This ongoing case series who underwent artificial corneal transplantation using the EndoArt^® device. Follow-up assessments were planned on 1 day, 1 week, 2 weeks, 1 month, and subsequently monthly for the initial 6 months followed by 3 monthly visits until one year. Pre and postoperative evaluations included a thorough examination, uncorrected (UCDVA) and best-corrected visual acuity (CDVA), corneal clarity, anterior segment ocular coherence tomography and pachymetry measurements.

Patient 1: An 80-year-old male with bilateral severe ocular surface disease and neurotrophic keratitis had a history of corneal melt and perforation needing a penetrating keratoplasty (PKP). He developed recurrent thinning and corneal melt in the periphery of the PKP leading to graft rejection and failure.  Patient 2: A 62-year-old male with a history of corneal decompensation following complicated extracapsular cataract surgery 34 years ago, pupil capture of the IOL with superior PMMA IOL in the anterior chamber and inferior IOL within the capsular fibrosis inferiorly and primary angle-closure glaucoma with  tube shunt. Patient 3: A 74-year-old female who had complicated cataract surgery, aphakia and significant pseudophakic bullous keratopathy. Patient 4: An 82-year-old female with ophthalmoplegia, previous bilateral Descemets Membrane Endothelial Keratoplasty (DMEK), recurrent VZV keratopathy and disciform keratitis in the right eye, right eye graft rejection, and elevated IOP.

All patients had anchor sutures for up to 4 weeks. Patient 1 needed to have a replacement of 2 anchor sutures after 4 weeks, along with rebubbling. Overall UCDVA improved in all cases with no other complications up to 4 weeks. Data of up to 9 months follow up will be provided in the meeting. Early results of EndoArt^® in complex corneal cases appear to be safe and effective.