Evaluating The Accuracy Of Intraocular Lens Power Calculations In Primary Angle-Closure Disease: A Comparative Analysis Of Seven Formulas

To compare the accuracy of seven intraocular lens (IOL) power calculation formulas, Barrett Universal Ⅱ (BU Ⅱ), Haigis, Hill-Radial Basis Function (Hill-RBF), Hoffer Q, Holladay Ⅰ, SRK/T and Kane in eyes with primary angle-closure disease (PACD).

University of Health Sciences, Beyoglu Eye Training and Research Hospital

Patients who underwent lensectomy with a diagnosis of PACD were included in the study. Seven formulas were used to calculate the IOL power. IOL implantation was performed according to Hoffer Q. To determine the accuracy of different formulas in PACD patients, the percentage of eyes with prediction error (PE) within ±0.50 diopter (D) and the mean absolute error (MAE) were compared. The median absolute errors (MedAE) were assessed.

Sixty-one eyes with PACD of 61 patients (39 female, 22 male) were enrolled. Mean age was 65.2±10.5 years. MedAE was highest in Hoffer Q with 0.88 D, and lowest in Hill-RBF with 0.61 D (Haigis: 0.77 D, BU II: 0.70 D, Holladay I: 0.65 D, Kane: 0.65 D SRK/T: 0.63). Although there was no significant difference in terms of MAE between the formulas (p=0.15), the formula with the lowest MAE was Hill-RBF (0.80±0.21 D) and the highest was Hoffer Q (0.92±0.28 D). The order of the formulas, from highest to lowest, in terms of percentage of eyes with PE within ±0.50 D were as follows: Holladay I (44.2%), Kane (42.6%), Hill-RBF (40.9%), SRK/T (40.9%), Hoffer Q (34.4%), BU II (31.1%) and Haigis (29.5%).

These findings underscore the variability in the accuracy of different IOL power calculation formulas in eyes with PACD. While no statistically significant differences were observed among the formulas, Holladay I, Kane, and Hill-RBF demonstrated the highest proportion of eyes within the ±0.50 D prediction error range, suggesting their potential superiority in refractive accuracy for this patient population.