ESCRS - FP09.13 - Highly Resolved Wavefront Sampling Of Intraocular Lenses

Highly Resolved Wavefront Sampling Of Intraocular Lenses

Published 2025 - 43rd Congress of the ESCRS

Reference: FP09.13 | Type: Free paper | DOI: 10.82333/h3v0-r658

Authors: Oliver Findl* 1 , Daniel Cheng 2

1Ophthalmology,Hanusch Hospital,Vienna,Austria, 2Johnson and Johnson MedTech,Irvine,United States

Purpose

Intraocular lens (IOL) design continues to evolve, offering refractive, diffractive, and extended-depth-of-focus (EDOF) solutions. Achieving optimal visual outcomes requires a thorough understanding of each lens’s subtle optical characteristics. In this work, we present a novel high-resolution wavefront reconstruction approach using a Mach-Zehnder interferometer (Nimo, Tempo, Lambda-X, Belgium) to analyze monochromatic light transmitted through multiple IOL designs at a wavelength of 543 nm.

Setting

Rothschild Foundation Hospital, CEROV

Methods

While the instrument’s software provides sagittal cross-sectional metrics, we leveraged comprehensive raw data acquisition to enable a three-dimensional, high-resolution reconstruction of the transmitted wavefront in monochromatic light (543 nm). Additionally, multiple custom-made wavefront fitting algorithms were applied to isolate fine variations in the optical path and reveal intricate features, including potential spiral (vortex) signatures. 

Results

Wavefront reconstruction encompassed diameters up to 6 mm, incorporating over 10 million data points. This unprecedented resolution allowed us to delineate the diffracted wavefront component at 543 nm in various bi and trifocal diffractive IOLs. Moreover, certain EDOF implants—marketed as non-diffractive—displayed subtle phase shifts consistent with a “step” or partial diffractive structure. Meanwhile, analysis of a spiral lens showed no vortex or spiral pattern but exhibited a pronounced negative spherical aberration.

Conclusions

Our three-dimensional, high-resolution wavefront analysis exposes nuanced optical features that conventional methods often overlook. This combined methodology allows us to infer the presence of refractive, diffractive, or hybrid optical features on the IOL, whether on its anterior or posterior surface, based on highly-resolved wavefront analysis. By objectively characterizing diverse IOL designs, these findings provide a robust foundation for refining lens technology, enhancing patient outcomes, and developing more realistic digital simulations of retinal image formation. This approach holds promise for further elevating both preclinical assessment and clinical performance of next-generation intraocular lenses.