ESCRS - FP03.06 - Discriminative Power Of Corneal Epithelial Aberrations, Anterior And Total Corneal Aberrations In Normal, Keratoconus, Subclinical, And Forme Fruste Keratoconus Eyes.

Discriminative Power Of Corneal Epithelial Aberrations, Anterior And Total Corneal Aberrations In Normal, Keratoconus, Subclinical, And Forme Fruste Keratoconus Eyes.

Published 2025 - 43rd Congress of the ESCRS

Reference: FP03.06 | Type: Free paper | DOI: 10.82333/0jpe-kc35

Authors: Kepa Balparda* 1 , Tatiana Herrera-Chalarca 1 , Mariana Escobar-Giraldo 2 , Isabela Franco-Sánchez 3

1Private Practice,Medellín,Colombia, 2Department of Ophthalmology,Universidad Pontificia Bolivariana,Medellín,Colombia, 3School of Medicine,Universidad Pontificia Bolivariana,Medellín,Colombia

Purpose

To compare the discriminative power of epithelial versus total corneal aberrations between normal and keratoconus (KC) eyes

Setting

Research Department at Ofttalmosalud, Instituto de Ojos, Lima, Peru.

Methods

Prospective cohort study including 205 eyes (60 normal eyes, 30 subclinical KC, 8 forme fruste keratoconus (FFKC), and 107 subclinical KC eyes (SCK). Epithelial corneal aberrations (EpiCA), anterior corneal aberrations (AntCA) and total corneal aberrations (TotCA) for the 6-mm pupil were measured using anterior segment OCT (MS-39) were obtained precisely: Total Root Mean Square (RMS), High Order Aberrations (HOAs), coma, trefoil, spherical aberration, and secondary astigmatism. The area under the ROC curve, sensitivity, and specificity were obtained from each variable.

Results

There were statistically significant differences between normal and KC eyes for all TotCA, AntCA, and EpiCA (p<.001). There were statistically significant higher aberrations in the SCK compared to normal eyes for Vertical coma from TotCA and AntCA and HOA from EpiCA. The higher AUROC value was for Vertical coma from AntCA (AUROC 0.76, cutoff 0.38, sensitivity 0.70, specificity 0.80). When evaluating FFKC and normal eyes, none of the TotCA, AntCA, and EpiCA were significantly higher than normal eyes.

Conclusions

Vertical coma from AntCA has the greater discriminatory power from aberrations measured at the total, anterior cornea, and epithelial levels.   Epithelial corneal aberrations don’t have higher discriminatory power between normal and subclinical Keratoconus eyes than anterior or total corneal aberrations.