Combined Platelet Rich Plasma And Amniotic Membrane Graft Versus Amniotic Membrane Graft Alone For The Treatment Of Perforated Central Corneal Ulcer
Published 2023 - 41st Congress of the ESCRS
Reference: PPE1.4 | Type: ESONT Abstracts | DOI: 10.82333/wvk9-zy65
Authors: Mohammed TAWFEEK* 1 , Sameh Fouda 2 , Ezzat Shahien 2 , Mahmoud Attia 3
1Lecturer of Ophthalmology,Zagazig Universtiy,Zagazig,Egypt, 2Professor of Ophthalmology,Zagazig Universtiy,Zagazig,Egypt, 3Resident of Ophthalmology,Zagazig Universtiy,Zagazig,Egypt
The aim of this work is to evaluate the safety and efficacy of combined use of topical platelet rich plasma (PRP) -PRP clot and eye drops- and amniotic membrane graft (AMG) in the management of corneal perforations and compare the results with AMG alone.
Zagazig University Hospitals.
This is an interventional comparative prospective randomized clinical study. Thirty-six eyes with infectious perforated central corneal ulcer. These eyes were classified into two groups each of 18 eyes. In group (A), eyes were treated by AMG combined with PRP clot to seal the central corneal perforation followed by PRP eye drops 6 times per day. In group (B), eyes were treated by AMG alone.
Most of the cases had anterior chamber formation within 24 hours; 88.9% and 72.2% in groups (A & B), respectively with statistically highly significant (P < .001), stability of the graft was better in group (A) with statistically significant difference (P = .041). Complete resolution of infectious perforated corneal ulcer was achieved in 17 eyes (94.4%) and 14 (77.8%) in groups (A & B), respectively with statistically highly significant difference (P <0.001). Failure was observed in only one eye (5.6%) in group (A) and in 4 eyes (22.2%) in group (B) with statistically highly significant difference (P < .001).
PRP clot and eye drops can be used as an available and effective adjuvant therapy to AMG for treating infectious central corneal perforation. This enhances the sealing of corneal perforation and anterior chamber (AC) reformation and fasten the healing of infectious perforated corneal ulcer with better visual improvement and less complications.