ESCRS - PP26.09 - Comparison Of Fibrin Glue Applied Over Corneal Surface Immediately After Pterygium Surgery: A Novel Pain Relief Technique

Comparison Of Fibrin Glue Applied Over Corneal Surface Immediately After Pterygium Surgery: A Novel Pain Relief Technique

Published 2023 - 41st Congress of the ESCRS

Reference: PP26.09 | Type: Free paper | DOI: 10.82333/ks6a-ts66

Authors: Bernardo Moscovici* 1 , Bianca Sussana 2 , Guilherme de Barros 3

1Unifesp,Sao Paulo,Brazil, 2Banco de Olhos de Sorocaba,Sorocaba,Brazil, 3Faculdade Medicina ABC,Santo andre,Brazil

Purpose

The purpose of this study was to compare the use of fibrin glue on the corneal epitheliectomy at the end of pterygium surgery versus conventional eye patch regarding pain levels, need for oral analgesic medications, number of days feeling pain, and awakening due to pain after surgery.

Setting

prospective, randomized, double-masked controlled trial

Methods

We included forty-eight eyes of twenty-four patients with bilateral primary pterygium . Each eye of the same patient was randomized to the intervention or control group. The intervention group received two drops of fibrin glue in the epitheliectomy at the end of surgery and an eye patch, while the control group was only on an eye patch. Patients returned on the first, and seven days after surgery. Pain levels, need for oral medications, the number of days the pain lasted, and quality of sleep were assessed during the follow-up visits and compared between groups. The comparison analysis accounted for gender, age, pterygium grading, and comorbidities.

Results

The pain perception after surgery was significantly lower in eyes receiving fibrin glue (-1.58; 95%CI: -2.84 a -0.32; p=0.014). Also, the intervention group presented a 73% lower chance of using oral analgesics (OR: 0.27; 95%CI: 0.07 to 0.95; p=0.041). No difference in the awakenings at night was noted (p=0.240) nor the mean days of ocular pain in the first week after surgery (p=0.474)

Conclusions

The application of fibrin glue at the end of pterygium surgery effectively reduces pain and the need for oral analgesics compared to conventional eye-patching. This study is the first to describe the results of this strategy, and further studies with a larger population are encouraged.