ESCRS - PP24.10 - 3.5 Years’ Experience With The Endoart Prosthetic Corneal Endothelial Prosthesis.

3.5 Years’ Experience With The Endoart Prosthetic Corneal Endothelial Prosthesis.

Published 2023 - 41st Congress of the ESCRS

Reference: PP24.10 | DOI: 10.82333/21y6-e269

Authors: Ruth Lapid-Gortzak* 1 , Ivanka van der Meulen 1

1Ophthalmology,Amsterdam UMC, University of Amsterdam ,Amsterdam,Netherlands

to report the 3 year results of the Dutch cohort of the first in human safety study of implantation of the EndoArt (Eye Yon Israel) in terms of safety, device adherence, adverse effects, and visual acuity.

Ophthaklmology Department Amsterdam UMC, location AMC, Amsterdam, the Netherlands

In a prospective safety study patients with endothelial failure, and poor visual prognosis from causes other than the cornea and lens were included. Previous glaucoma, corneal surgery or corneal disease was an exclusion criterium. In 7 patients the diseased endothelium was removed and replaced by the Endoart, a novel artificial endothelial device. The EndoArt is a dome shaped acrylic disc of 6.5mm that functions as physical barrier device precluding inflow of fluid from the AC into the corneal stroma. It enables a new fluid equilibrium in the corneal stroma and thus decreases stromal edema.

In 7 patients the EndoArt device was implanted. All 7 patients reached the endpoint of  year follow up within the study. The endoart remained adherent until the last follow up. 6 patients returned for follow up visits beyond the study duration. Follow up ranged from 12 months to 42 months. In 3/6 patients the visual acuity improved (even though this was not expected). In 4 out of 7 a suture was used to aid initial adherence. No pathological thinning of the cornea seen, neither were any other adverse effects observed. Central cornea thickness on OCT was reduced by a mean of 26.8%. In 1 patient no effect was seen. Rebubbling rates were reduced after introduction of a temporary suture at the time of surgery to aid adherence of the endoart.

The 

EndoArt remained in situ in all patients of this cohort. In most patients intended corneal thinning and alleviation of stromal edema was observed. No ocular or other side-effect or complications were seen. Adherence improved by use of a suture. The use of a suture reduced the rebubbling rates significantly. More study is needed.