Baseline Characteristics Of Participants In The Concept Randomised Controlled Trial (Comparing Phaco Vs Phaco With Endoscopic Cyclophotocoagulation)
Published 2023 - 41st Congress of the ESCRS
Reference: PP23.11 | DOI: 10.82333/zg29-ys56
Authors: Kin Sheng Lim* 1 , Thomas Edward James Sherman 1 , Saurabh Goyal 2 , Ian Rodrigues 2 , Pouya Alaghband 3 , Andrew Swampillai 4 , Panagiota Founti 5 , Hari Jayaram 5 , Keith Barton 5 , Mohammed Abu-Bakra 6 , Philip Bloom 7
1Faculty of Life Sciences and Medicine,King's College London,London,United Kingdom;Ophthalmology,Guy's and St Thomas' NHS Foundation Trust,London,United Kingdom, 2Ophthalmology,Guy's and St Thomas' NHS Foundation Trust,London,United Kingdom, 3Ophthalmology,York Hospital,York,United Kingdom, 4Ophthalmology,Guy's and St Thomas' NHS Foundation Trust,London,United Kingdom;Faculty of Life Sciences and Medicine,King's College London,London,United Kingdom, 5Ophthalmology,Moorfields Eye Hospital,London,United Kingdom, 6Ophthalmology,Queen Mary's Hospital,Sidcup,United Kingdom, 7Ophthalmology,Western Eye Hospital,London,United Kingdom
To describe baseline characteristics of participants enrolled in the CONCEPT randomised controlled trial. The
study will compare the effectiveness of phacoemulsification with endoscopic cyclophotocoagulation (ECP) laser to
phacoemulsification alone for patients with cataract and primary open angle glaucoma (POAG), or pigmentary glaucoma
at 1 and 2 years post-surgery.
4 UK based centres (St Thomas' Hospital London, York Hospital North Yorkshire, Moorfields Eye Hospital London, Western Eye Hospital London, Queen Mary's Hospital Sidcup) enrolled patients from March 2020 to October 2022 to participate in the study.
All participants have mild to moderate glaucoma and undergo washout diurnal intraocular pressure (IOP) measurement at
baseline. Repeat washout IOP measurement is planned at 1 and 2 years postop. Patients have a cataract with vision of
6/9 or worse and no history of prior glaucoma surgery, but may have had previous selective laser trabeculoplasty.
Participants are randomised to receive phacoemulsification alone or combined with ECP at the point of uneventful
cataract surgery. The study is registered on clinicaltrials.org (NCT04295122).
162 participants were recruited. The mean age is 70.5 (8.3) with 85 male and 77 female participants. There is
an approximately equal split of Caucasian participants (45.68% n=74) and African/Caribbean participants (49.38% n=80).
The majority (96.3%) have POAG and remainder pigmentary glaucoma. Average baseline acuity is 0.36 (0.19) logMAR,
with a low myopic spherical equivalent (-0.96D +/-3.02). As included glaucoma cases are mild/moderate, the mean visual
field mean deviation is -4.75dB (3.49), with 1.75 (1.09) mean medications preop. Following washout of glaucoma
medications the mean baseline IOP was 25mmHg (4.7) with 36 participants (21.6%) having an IOP of >30mmHg.
The CONCEPT study is the first ever randomised controlled study to compare phacoemulsification with
ECP to phacoemulsification alone in open angle glaucoma. The balanced split of Caucasian and African/Caribbean
participants will allow for novel comparison of different ethnicities response to ECP and safety in these groups.