Long-Term Changes Of Corneal Power In Young Keratoconus Patients With Progression And Non-Progression

Published 2023 - 41st Congress of the ESCRS

Reference: PP11.10 | Type: Free paper | DOI: 10.82333/4bk8-e541

Authors: Masaki Kinoshita* ¹ , Shizuka Koh ² , Ryota Inoue ³ , Renato Ambrósio, Jr. ⁴ , Takeshi Soma ¹ , Yoshinori Oie ¹ , Naoyuki Maeda ¹ , Kohji Nishida ¹

¹Department of Ophthalmology,Osaka University Graduate School of Medicine,Osaka,Japan, ²Department of Ophthalmology,Osaka University Graduate School of Medicine,Osaka,Japan;Department of Innovative Visual Science,Osaka University Graduate School of Medicine,Osaka,Japan, ³Department of Innovative Visual Science,Osaka University Graduate School of Medicine,Osaka,Japan;SEED CO.,LTD.,Tokyo,Japan, ⁴Instituto de Olhos Renato Ambrósio/Visare Personal Laser and Department of Ophthalmology,Federal University of the State of Rio de Janeiro (UNIRIO),Rio de Janeiro,Brazil

Purpose

To retrospectively investigate long-term changes of corneal power in young keratoconus (KC) and compare corneal powers between eyes with progression and non-progression by Fourier analysis using anterior segment optical coherence tomography (OCT).

Setting

Osaka University Hospital, Osaka, Japan

Methods

Thirty-nine eyes of 33 patients were enrolled. Inclusion criteria were; 1) at least one eye had abnormal KC findings on slit-lamp microscopy or/and Placido topography, 2) younger than 25 years old at the first visit with a minimum follow-up of 2 years. Based on Scheimpflug-based tomography examination, eyes were divided into progression (P) and non-progression (NP) groups. Fourier analysis using OCT decomposed dioptric data from both anterior and posterior corneal surfaces into spherical, regular astigmatism, asymmetry, and higher-order irregularity components in the central 6mm zone. Changes in each Fourier component between initial and last visits between two groups were compared.

Results

Enrolled eyes were divided into 13 eyes as P group and 26 eyes as NP group. Changes in anterior spherical component (P: 0.88±1.93D, NP: -0.47±0.57D), anterior higher-order irregularity component (P: 0.04±0.13D, NP: -0.00±0.05D), and posterior spherical component (P: -0.15±0.32D, NP: 0.01±0.04D) were significantly greater in P group than in NP group (p<0.05, all). Other Fourier parameters showed no significant differences between the two groups.

Conclusions

Based on the quantitative Fourier analysis of corneal power with OCT over a 2-year period, significant increase in anterior spherical, anterior higher-order irregularity, and posterior spherical components were observed in young KC with progression than in those without progression.