Assessment Of Corneal Angiography Filling Patterns In Corneal Neovascularization
Published 2023 - 41st Congress of the ESCRS
Reference: PP02.14 | Type: Free paper | DOI: 10.82333/d8vd-4a37
Authors: Luca Pagano 1 , Alfredo Borgia* 1 , Haider Shah 1 , Kunal Gadhvi 1 , Mohammad Ahmad 1 , Nardine Menassa 1 , Giulia Coco 2 , Stephen Kaye 1 , Vito Romano 3
1Royal Liverpool University Hospital,Liverpool,United Kingdom, 2Department of Clinical Science and Translational Medicine,University of Rome Tor Vergata,Rome,Italy, 3ASST Spedali Civili di Brescia,Brescia,Italy
Purpose
To describe vascular filling patterns in corneal neovascularization (CoNV) and evaluate the effect of corneal lesion location, CoNV surface area and multi-quadrant CoNV involvement on the filling pattern.
Setting
Retrospective study of patients who were investigated for CoNV at the Royal Liverpool University Hospital using fluorescein angiography (FA) or indocyanine green angiography (ICGA) between January 2010 and July 2020.
Methods
Angiography images were graded and analyzed multiple independent corneal specialists. The corneal surface was divided into four quadrants and patient information was obtained through electronic records. A total of 133 eyes were analyzed.
Results
Corneal lesions were located on the peripheral (72%) or central (28%) cornea. Central lesions were associated with multi-quadrant CoNV more frequently than peripheral lesions (p = 0.15). CoNV located within the same quadrant of the corneal lesion was often first to fill (88.4%). In multi-quadrant CoNV, the physiological inferior– superior–nasal–temporal order of filling was usually respected (61.7%). Central lesions resulted in larger CoNV surface area than peripheral lesions (p = 0.09). In multi-quadrant CoNV, the largest area of neovascularization was also the first to fill in (peripheral lesion 74%, central lesion 65%).
Conclusions
Fillings patterns in healthy corneas have previously been reported. Despite CoNV development, these patterns are usually respected. Several factors that may influence filling patterns have been identified, including corneal lesion location, CoNV surface area and aetiology of CoNV. Understanding filling patterns of neovascularization allows for the identification of areas at higher risk of developing CoNV, aiding in earlier detection and intervention of CoNV.