Allogenic Corneal Lenticule For Hyperopia: Five-Year Visual And Corneal Densitometry Outcomes In 20 Eyes

Published 2023 - 41st Congress of the ESCRS

Reference: PO1015 | Type: Free paper | DOI: 10.82333/rhxs-jv08

Authors: Cafer Tanrıverdi* ¹ , Zeki Yiğit Karaca ¹ , Fatma Feyza Nur Keskin Perk ¹ , Ziya Burke ¹ , Aylin Kılıç ¹

¹Ophthalmology,Medipol University,Istanbul,Türkiye

Purpose

To evaluate 5-year clinical results and topographic findings of allogenic corneal lenticule for hyperopia treatment.

Setting

Istanbul Medipol University Hospital, Ophthalmology Department, Istanbul, Turkey

Methods

This cross-sectional study included 20 eyes of 11 patients with a follow-up of 5 years.Allogenic corneal lenticules(Allotex) were implanted in hyperopic individuals whose manifest refraction spherical equivalent(MRSE) ranged from +1.00 to +6.00D and cylindrical refraction less than 1D.Uncorrected and best-corrected distance and near(40 cm) visual acuities(UCDVA,BCDVA,UCNVA,BCNVA),and MRSE were evaluated.Changes in topographic parameters including Kmean,central corneal thickness(CCT),and corneal densitometry values for three different layers(anterior, central, posterior) and zones(0-2mm, 2-6mm,and 6-10mm)were compared.Total corneal densitometry parameters were also included.Corneal densitometry values were evaluated as gray scale units(GSU).

Results

UCDVA and UCNVA were significantly increased(both p<0.01),while BCDVA and BCNVA weren’t significantly changed in a five-year follow-up(p=0.368, p=0.052,respectively).MRSE was significantly decreased (p<0.01).Kmean and CCT values were significantly increased,showing the steepening and corneal thickening related to tissue addition(both p<0.01).Corneal densitometry was significantly increased in the anterior and central layers and between 0-6mm zones,while there was no significant change in the posterior layer and the 6-10mm zone.Anterior 0-2 mm area showed the greatest increase(preoperatively 18.91±3.32 GSU,and 19.87±1.93 GSU at postoperative 5th-year,p=0.044).Quantity of increase was reduced with increasing measurement diameter and depth.

Conclusions

The use of an allogenic hyperopic corneal lenticule is a safe and successful therapeutic option, according to 5-year visual and topographic outcomes. As a tissue addition to the cornea is made, a rise in corneal densitometry is likely to be expected; however, although statistically significant, the amount of increase is negligible. Allogenic corneal lenticules may become widely used in the treatment of hyperopia in the upcoming years, considering the generally poor success rate of treatment options in this patient population.