Use Of  Human Lyophilized Amniotic Membranes For Surface Reconstruction                                                            

To report the outcomes of using human lyophilized amniotic membrane with sponge layer preservation  (Visio Amtrix S)    in the reconstruction of ocular surface. 

Case series, illustrated with slit-lamp and surgery images

A case serie of 6 patients with ocular surface pathologies were treated with Visio Amtrix  in Miranza, Sevilla. The main outcomes measures were healing response of epithelial defects (reepithelization), visual acuity and membrane integration measured by OCT  after application of Visio Amtrix S.The amniotic membrane was placed on the corneal/conjunctival defect, either inlay or overlay (depending of the case), trimmed and sutured with interrupted 10/0 nylon, and removed at one month. 

A total 6 patients (4 males, 2 females)  between 63 a 96 years (76 +/-10) with a spectrum of different etiologies (2  band keratopathy ,3 ocular surface squamous neoplasia (OSSN), 1 neurotrophic ulcer,) were followed for a mean 18 months (range 11 to 26). All  of the eyes showed decrease in the size of epithelial defects  and complete healing without any side effects. Patients with OSSN have had better  results  and showed better visual acuity . Vision improved in 66%  of the study population and remained stable in 16%.The  patient with neurotrophic ulcer  and corneal melting, with Visio Amtrix he remains stable , without risk of perforation. The OCT images demonstrated thickness increase of the thin zone. 

Visio Amtrix  can be easily applied in the clinical setting and has demonstrated its efficacy  as a new tool to treat  corneal and conjunctiva epithelial  defects.