ESCRS - PO0734 - Comparison Of Different Retinal Layers Thicknesses Between Healthy, Subclinic Keratoconus And Keratoconus Eyes

Comparison Of Different Retinal Layers Thicknesses Between Healthy, Subclinic Keratoconus And Keratoconus Eyes

Published 2023 - 41st Congress of the ESCRS

Reference: PO0734 | DOI: 10.82333/r9c7-tx18

Authors: Neus Burguera Giménez 1 , Celeste Briceno Lopez 2 , Mª Amparo Díez-Ajenjo 3 , Mª Jose Luque-Cobija 3 , Noemi Burguera 4 , Cristina Peris Martínez* 5

1Cornea and anterior segment,Fundación de Oftalmología Médica de la Comunitat Valenciana,Valencia,Spain;Optics, Optometry, and Visual Sciences,University of Valencia,Burjassot,Spain, 2Cornea and anterior segment,Fundación de Oftalmología Médica de la Comunitat Valenciana,Valencia,Spain;UVEG-Alcon Cathedra,Valencia,Spain;Optics, Optometry, and Visual Sciences,University of Valencia,Burjassot,Spain, 3Optics, Optometry, and Visual Sciences,University of Valencia,Burjassot,Spain;UVEG-Alcon Cathedra,Valencia,Spain, 4Ophthalmology department,Qvision, Vithas Virgen Del Mar Hospital,Almeria,Spain, 5Cornea and anterior segment,Fundación de Oftalmología Médica de la Comunitat Valenciana,Valencia,Spain;Surgery Department, Ophthalmology,School of Medicine, University of Valencia,Valencia,Spain;UVEG-Alcon Cathedra,Valencia,Spain

To compare macular ganglion cell-inner plexiform layer (GCIPL), ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) and outer retinal layer (ORL) thicknesses between healthy, keratoconus (KC) and subclinic KC eyes.

Fundación de Oftalmología Médica de la Comunitat Valenciana (FOM)

Universitat de Valencia

This cross-sectional and prospective case-control study included 110 eyes of 59 KC and 51 healthy patients aged between 18 and 50 years. GCIPL, GCC, RNFL and ORL were automatically obtained and defined by the ETDRS style grid from Swept-Source OCT using the 12 mm line scan pattern. Only eyes with axial length (AL) between 22 and 26 mm were included. Only central ring from ETDRS grid was considered. KC eyes were stratified in 2 groups considering the topographic KC classification (TKC): subclinic KC, TKC=possible and fellow eye with diagnosed KC (n= 16) and established KC, TKC>1(n=43). Shapiro-Wilk test showed that most variables were not normally distributed, hence, Kruskal-Wallis test was run to explore thickness variations between groups.

All groups were aged-matched (mean age control: 31 ± 9; subclinic KC: 32 ± 9, and KC: 29 ± 10 years, p > .05). Control and KC groups were AL-matched (23.6 ± 0.9 vs. 23.9 ± 1.1 mm, p > .05), however, healthy and subclinic KC were significantly different (23.6 ± 0.9 vs. 24.5 ± 0.9, p = .012). Similar values of GCC and GCIPL were observed between all groups (GCC: control 57 ± 8 μm, subclinic KC 61 ± 6 μm, and KC 57 ± 10 μm, p > .05; GIPL: control 49 ±7 μm, subclinic KC 51 ± 5 μm, and KC 48 ± 10 μm, p > .05). Non-significantly thinner values of RNFL thickness in control (8 ± 3 μm) were observed, followed by KC (9 ± 5 μm) and subclinic KC (10 ± 2 μm). Non-significantly thicker ORL thickness in subclinic KC (132 ± 22 μm) were observed,  p > .05.

 

Non-significantly differences have been found in different retinal layers thicknesses between pathological and non-pathological eyes. Subclinic KC presented non-significantly thicker values of all retinal layers thicknesses compared to healthy and KC eyes. Although there is evidence about the involvement of posterior segment in the KC disease, further investigations are needed to understand the role and implication of the retinal structure in the KC pathogenesis.