7Mm Frozen And Dried-Preserved 50Um Amnion Disc (Ad) In Wound Healing Following Athens Protocol Cxl For Keratoconus-A Comparative Study
Published 2023 - 41st Congress of the ESCRS
Reference: PO0691 | DOI: 10.82333/sxz4-md54
Authors: Anastasios John John Kanellopoulos* 1 , Alexandros John Kanellopoulos 2
1Ophthalmology,LaserVision Ambulatory Eye Surgery Unit,Athens,Greece;Ophthalmology,NYU Med School,New York,United States, 2Ophthalmology,LaserVision Ambulatory Eye Surgery Unit,Athens,Greece
Compare the safety and efficacy of using a 7mm disc of 50um amnion in Athens protocol CXL ( CXL combined with a surface excimer ablation)
Laservision Ambulatory Surgical Center, Athens, Greece.
30 cases that underwent AP for progressive KCN were randomized to receive prior to the bandage contact lens placement at the end of the procedure an epithelial-side up 7mm in diameter 50um in thickness amnion disc that was applied dehydrated on the stromal surface and attached by natural hydration, covered by the standard for our routine bandage contact lens.
All eyes were evaluated daily up to complete re-epithelization, at month 1 and month 3 postoperative by slit lamp biomicrocopy, and fluorescein staining. All refractive data were evaluated as well preoperatively as well as each eye graded during the first postoperative night subjectively by the patient on a scale 0 to 4, 0 being no discomfort, 4 being severe discomfort
All eyes re-epithelialized by day 6. 15 eyes with adjunct Ad by day 4 vs 1 non Ab eye. There were no differences in UDVA, CDVA and residual refractive error between the 2 groups. There was statistical difference in epithelial mapping at 1 month only between the Ad group and the non Ad group, with the former demonstrating smoother epithelial remodeling. Ad pain score 0.4, non-Ad: 1.8= statistically significant.
Thin amnion disc used as an adjunct bandage in AP CXL may accelerate re-epitheliazation, improve first day pain profile and also improve epithelial remodeling within the first postoperative month.