ESCRS - PO0661 - A Comparison Of The Corneal Thickness Following Descemet’S Stripping Automated Endothelial Keratoplasty And Descemet’S Membrane Endothelial Keratoplasty

A Comparison Of The Corneal Thickness Following Descemet’S Stripping Automated Endothelial Keratoplasty And Descemet’S Membrane Endothelial Keratoplasty

Published 2023 - 41st Congress of the ESCRS

Reference: PO0661 | Type: Free paper | DOI: 10.82333/4mcb-yw29

Authors: Chihiro Sunouchi* 1 , Takahiko Hayashi 2 , Toshiki Shimizu 3 , Yusuke Hara 3 , Junki Kurita 3 , Akira Kobayashi 4 , Jun Shoji 5 , Satoru Yamagami 3

1Ophthalmology,Higashi Matsuyama municipal hospital,Tokyo,Japan, 2Ophthalmology,Nihon University School of Medicine,Tokyo,Japan;Ophthalmology,Yokohama Minami Kyosai Hospital,Kanagawa,Japan, 3Ophthalmology,Nihon University School of Medicine,Tokyo,Japan, 4Ophthalmology,Kanazawa University Graduate School of Medical Science,Kanazawa,Japan, 5Ophthalmology,Nihon University School of Medicine,Tokyo,Japan;Ophthalmology,Shoji Eye Clinic,Chiba,Japan

Purpose

To compare the central corneal thickness before and after Descemet’s stripping automated endothelial keratoplasty (DSAEK) and Descemet’s membrane endothelial keratoplasty (DMEK), and to evaluate the recipient corneal thickness following DSAEK.

Setting

Retrospective cohort study.

Methods

All patients underwent DSAEK and DMEK by a single surgeon (T.H.) between 2015 and 2017. We included DSAEK and DMEK eyes (n = 26 each), which were similar in terms of their etiologies.  We evaluated the following factors preoperatively and at 1, 3, and 6 months postoperatively in all eyes: best spectacle-corrected visual acuity (BSCVA; a logarithm of the minimal angle of resolution [logMAR]) and topographic factors determined by anterior segment optical coherence tomography (CASIA, Tomey, Nagoya, Japan), namely CCT and graft thickness. Recipient corneal thickness (RCT) was defined as the corneal thickness without graft thickness.

Results

The preoperative logMAR was matched to 0, and the postoperative logMAR was evaluated by the amount of change used a mixed effects model for statistical investigation. Statistical analysis revealed that BSCVA improved gradually (P < .01); nonetheless, there was no difference between the surgical techniques(P = .28). Preoperatively, there was no significant difference in the central corneal thickness between the groups (P = 0.30). Despite the tendency of the central corneal thickness to be significantly greater (P < .01) at 6 months following DSAEK compared with that following DMEK, there was no significant difference at 6 months between the recipient corneal thickness following DSAEK and central corneal thickness following DMEK (P = 0.54).

Conclusions

This study suggests that DSAEK eyes display a similar tendency of stromal thinning as DMEK eyes. The RCT following DSAEK displayed aberrant thinning during the study; we observed a similar thickness course of the CCT following DMEK. Researchers should elucidate the clinical significance of these thickness changes following endothelial keratoplasty in the future.