Granular Dystrophy Type 1 Or Type 2 ?
Published 2023 - 41st Congress of the ESCRS
Reference: PO0140 | Type: Case report | DOI: 10.82333/y6h1-xc46
Authors: Gamze Saricicek* 1 , Aysun Sanal Dogan 1
1Ophtalmology,Dışkapı Yıldırım Beyazıt Training and Research Hospital,Ankara,Türkiye
In this case report, a 77-year-old male patient was defined as granular dystrophy type 1 using histological staining methods and confocal microscopy. The clinical features of the patient who was evaluated with a preliminary diagnosis of granular corneal dystrophy were emphasized, the disease was subtyped histopathologically, treatment planning and results were discussed.
This was a case report and designed at Departments of Ophtalmology, Dışkapı Yıldırım Beyazıt Training and Research Hospital, Ankara, Turkey
A 77-year-old male patient was admitted to our clinic with complaints of decreased vision in both eyes, occasional stinging, and photophobia. The patient's history was unremarkable except for type 2 DM and benign prostatic hyperplasia. It was learned that his brother had similar complaints in his eyes, and that he had undergone penetrating keratoplasty and phaco surgery. The visions were 1mps OD, 0.05 OS (does not increase with correction). He had right dominant exophoria. In the corneal stroma of both eyes, there were transparent stromal opacities, clustered in the center, ring and star-shaped, not extending to the limbus, with higher density in the anterior stroma. Corneal lesions were also observed in OCT, corneal topography and in-vivo confocal microscopy. The patient was clinically diagnosed with Granular Dystrophy type 2 (GCD2) and cataract. Phaco, IOL implantation and penetrating keratoplasty (as a triple procedure) was performed on the right eye of the patient. In the postoperative follow-ups, the patient's vision reached the level of 0.2 on the right. The corneal tissue for which pathological studies were performed was stained as + with Masson's trichrome and as - with Crystal violet.
It is not always possible to distinguish corneal dystrophies on the basis of their phenotypic and clinical features. The appearance may be different at the beginning and in the adult period, and may change over time. When corneal dystrophies are suspected clinically, genetic examination is needed to make a definitive diagnosis. Genetic examination provides important clues in terms of prognosis and treatment approach as well as diagnosis.