Effect Of Oral Vitamin D Supplementation On Dry Eye Disease Patients With Vitamin D Deficiency
Published 2023 - 41st Congress of the ESCRS
Reference: FP26.06 | Type: Free paper | DOI: 10.82333/bav5-et83
Authors: Alireza Eslampoor* 1 , Siamak Zarei Ghanavati 1 , Marzieh Najjaran 2
1Ophthalmology,Mashhad University of Medical Sciences,Mashhad,Iran, Islamic Republic Of, 2Optometry,Mashhad University of Medical Sciences,Mashhad,Iran, Islamic Republic Of
Purpose
This study aimed to determine the therapeutic effect of oral vitamin D supplementation in dry eye disease patients with vitamin D deficiency
Setting
Randomized controlled study
Methods
A randomized, controlled study was completed in 100 patients with dry eye disease and
concurrent vitamin D deficiency (< 20 ng/ml). Participants were randomly allocated to 8 weeks of oral
vitamin D supplementation, with both groups receiving conventional dry eye treatment with artificial
tears. Schirmer’s tear break-up time (TBUT) and osmolarity tests were measured before and after
eight weeks of treatment.
Results
The mean age of participants was 36.8 ± 8.56 years in the treatment group (n: 50) and
34.8 ± 10.13 years in the control group (n: 50). After eight weeks of treatment, the mean differences in
Schirmer’s, TBUT and tear osmolarity were 2.38 ± 1.55 mm, 3.95 ± 1.48 s and −16.9 ± 6.28 mOsm/L,
respectively in the treatment group, and 0.7 ± 0.86 mm, 0.92 ± 1.57s and −3.34 ± 2.0 mOsm/L
respectively in the control group (p < 0.001 for all parameters). The treatment group demonstrated
a more significant improvement than the control group in Schirmer’s, TBUT and osmolarity values
(p < 0.001).
Conclusions
Vitamin D supplementation as an adjuvant to routine dry eye treatment improves ocular
surface hemostasis parameters result in better tear stability and a more improved tear osmolarity in
patients with vitamin D deficiency.