ESCRS - FP11.02 - Agreement And Repeatability Of Axial Length And Main Ocular Biometric Endpoints Between Vemos-Axl And Iolmaster 700 For The Vemos Project Software Validation.

Agreement And Repeatability Of Axial Length And Main Ocular Biometric Endpoints Between Vemos-Axl And Iolmaster 700 For The Vemos Project Software Validation.

Published 2023 - 41st Congress of the ESCRS

Reference: FP11.02 | Type: Free paper | DOI: 10.82333/rtxs-ar41

Authors: Marina Jose Martinez* 1 , Antonio Martínez-Abad 1 , Ana B. Plaza-Puche 1 , Alejandra E. Rodriguez 1 , Henrik Sejersen 2 , Jesper Hjortdal 2 , Joaquim Murta 3 , Francesco Versaci 4 , Jorge L. Alió 5

1Research and Development Department,Vissum Grupo Miranza,Alicante,Spain, 2Department of Opthalmology,Aarhus University Hospital,Aarhus,Denmark, 3Department of Opthalmology,University of Coimbra,Coimbra,Portugal, 4CSO (Construzioni Strumenti Oftalmici),Firenze,Italy, 5Department of Cornea and Refractive Surgery,Vissum Grupo Miranza,Alicante,Spain;School of Medicine,Miguel Hernandez University,Alicante,Spain

Purpose

The European VEMoS Project consists in virtually reconstructing the patients´ eye using biometric data as inputs, which are extracted from the devices designed specifically for this project. Achieving a more accurate profile of the patient´s eye would ensure more realistic results, which is why it is considered of high importance to check that the input parameters are precise. In order to evaluate the biometric parameters obtained from the new topographer designed for the project (VEMoS-AXL), a comparative analysis is carried out with these data and that provided by the IOLMaster 700 for participants with long eyes (AL > 26mm). In addition, the repeatability of the axial length obtained from the VEMoS-AXL topographer is also evaluated.

Setting

Vissum Grupo Miranza, Alicante, Spain.

Methods

The study included 37 healthy eyes of 37 patients (mean age of 31.46 ± 7.09 years) all of which have an axial length (AL) greater than 26mm. Eye examinations were performed with MS-39 AXL (CSO) and IOLMaster 700 (Zeiss) and ocular biometric parameters were collected and compared. To evaluate the repeatability of the 6 consecutive measurements given by the MS39 AXL, within-subject standard deviation (Sw) and the intraclass correlation coefficient (ICC) were performed. Kolmogorov-Smirnov test (p>0.05) confirmed the normality of the sample. Taking into account a significance level of 0.05, Paired T-test was performed to compare ocular biometric parameters between both devices.

Results

The repeatability analysis of AXL revealed a Sw of 0.0048 and an ICC of 0.99. Mean AL, anterior chamber depth (ACD) and corneal central thickness (CCT) showed statistical differences between devices (p<0.05). However, at a clinical level, this might not have a significant implication as, according to descriptive analysis, the mean was 26.69±0.51mm with MS-39 AXL and 26.66±0.51mm with IOLMaster, for the AL, with a difference of 0.03mm. The differences are also acceptable for ACD y CCT, with a difference of 0.11mm and 0.003mm respectively, and present strong correlations between measurements (rho>0.90, p <0.001).

Conclusions

For a group of healthy eyes, with an AL > 26mm, high intra-subject repeatability is obtained. For the three biometric parameters analyzed, there are significant differences between devices, however, at a descriptive level, the difference is minimal and the correlation high, therefore it is clinically acceptable. ACD values ​​vary slightly more possibly due to the accommodation effect of young eyes. On the other hand, an increase in the sample size would provide more precise and solid results.