Investigating The Antimicrobial Activity And Toxicity Of Repeated Application Of 1% Povidone-Iodine Compared To A Single Application Of 5% Povidone-Iodine
Published 2023 - 41st Congress of the ESCRS
Reference: FP08.11 | Type: Free paper | DOI: 10.82333/7bh5-xt98
Authors: David Teren* 1 , gil Neuman 1 , Evgeny gelman 1 , Elishai Assayag 1 , Orna Schwartz Harari 2 , Abeer hajj 2 , Adi Abulafia 1 , DAVID Zadok 1
1ophthalmology,shaare zedek ,jerusalem,Israel, 2microbiology,wolfson MC,holon,Israel
Purpose
The purpose of this study is to demonstrate the in vivo non-inferiority antimicrobial activity of repeated applications of 1% Povidone-Iodine (PI) on the ocular surface in comparison to a single application of 5% PI. Additionally, the study will assess the corneal epithelial toxicity.
Setting
This prospective randomized, double-blind study was conducted at the Department of Ophthalmology at Shaare Zedek Medical Center, Jerusalem, Israel.
Methods
This prospective randomized, double-blind study was conducted at the Department of Ophthalmology at Shaare Zedek Medical Center, Jerusalem, Israel. Patients undergoing routine cataract surgery were randomly assigned to receive either a single application of 5% PI or repeated applications of 1% PI as preoperative ocular surface irrigation. Conjunctival swabs were taken before and after the irrigation in a standardized manner to quantify the number of bacterial colonies. The difference in bacterial colony counts between the two groups was then compared. After collecting the samples, all patients were assessed for superficial punctate keratopathy (SPK) and were graded based on the National Eye Institute (NEI) grading system.
Results
The study comprised 102 eyes of 102 patients with an average age of 73.5±9.27 years.The use of either 1% or 5% PI resulted in a marked decrease in bacterial colonies compared to pre-application (P < 0.001). The repeated application of 1% PI showed a significantly lower bacterial count compared to the single application of 5% PI (P < 0.05). Furthermore, the repeated use of 1% Povidone-iodine resulted in significantly less damage to the corneal epithelium compared to the single use of 5% Povidone-iodine (1.68 ± 1.80 vs. 7.98 ± 3.54, P < 0.001).
Conclusions
The results of this study suggest that repeated irrigation with 1% PI is more effective in reducing bacterial growth on the ocular surface when compared to a single irrigation with 5% PI. Additionally, the findings show that 1% PI has a significantly lower risk of causing damage to the corneal epithelium compared to 5% PI.