Illuminating Aqueous Hydrodynamics In Digital Reality Using A 3D Finite Element Model
Published 2022
- 40th Congress of the ESCRS
Reference: FPM04.06
| Type: Free paper
| DOI:
10.82333/emw5-fg06
Authors:
Laurent Sabatier* 1
, AnnMarie Hipsley 2
, Daniel Goldberg 3
1Digital Engineering & Research,Ace Vision Group Inc,Cocoa Beach,United States, 2Digital Engineering & Research,Ace Vision Group Inc,Newark,United States, 3ophthlamology,Atlantic Eye,Little Silver,United States
Purpose
To present a Fluid Structural Interaction analysis (FSI analysis) ,Finite Element Analysis (FEA) and Computational Fluid dynamics (CFD) of aqueous humor dynamics of young and presbyopic eyes to explore the age-related changes.
Setting
Research was performed in a private independent research project.
Methods
Simulation of ocular hydrodynamics during phases of disaccommodation/accommodation as created using a Computational Fluid Dynamics (CFD) model in fluid simulation software (Ansys, Inc) based on a Finite Element Model (FEM). Fluid structure interaction (FSI) was used to quantify human ocular hydrodynamics. Key anatomical structures were incorporated including the sclera, ciliary muscles, crystalline lens, lens capsule, zonules, choroid, Schlemm's canal and trabecular meshwork. Analysis of the potential pathogenesis of age related ocular hypertension were explored in virtual reality (VR) under varied conditions. Simulations of Laser Scleral Microporation (LSM) procedure were performed to explore mechanisms of action (MOA) for IOP reduction.
Results
The multiphysics FSI demonstrated the dynamic fluid flow occurring during the phases of disaccommodaitn -accommodation-disaccommodation. Our model was able to demonstrate the aqueous humor pathways in VR under various scenarios of age and disease. We were also able to validate the model against literature and create "what if scenarios" for various treatment for ocular hypertension and glaucoma. We further demonstrated a potential MOA of the LSM treatment and its effects on hydrodynamics through outflow channels.,
Conclusions
This multiphysics FSI simulation is capable of giving us a deeper understanding of the aqueous humor flow pathways during the cycle of disaccommodation and accommodation. We are now able to simulate and visualize aqueous humor dynamics undervarious scenarios in 3D VR. We also successfully tested the model's capability of quantifying a MOA for the therapeutic procedure (LSM) in VR. The future utility of exploring MOA in VR for various treatments, surgeries, and therapies has extraordinary potential in not only undrestanding the pathogenesis of ocular hypertension and glaucoma but also to explore MOA's in VR for various surgical and therapeutic interventions.