Promising Therapy for radiation maculopathy
Intravitreal pharmacotherapy may moderate anatomic and visual effects of radiation-associated maculopathy


Sean Henahan
Published: Wednesday, January 11, 2017

Timothy Murray MD
Of most importance to the patients, at two months visual acuity had improved to 20/51, and at six months had improved to 20/32He described several cases where patients demonstrated dramatic improvement. One such case was a 76-year-old patient who had 20/400 BCVA at the beginning of the study. After receiving anti-VEGF treatment at six week intervals he improved to 20/30, with significant improvement also noted on OCT. Another patient, enrolled eight months post-brachytherapy, presented with both radiation maculopathy and optic neuropathy. After 66 weeks on the treat-and-extend protocol she also showed marked improvement on her OCT, with visual acuity improving from 20/400 to 20/30. “Ultimately, this interim data does suggest the potential for a large, multicentre randomised controlled clinical trial, and supports the recent shift within the ocular oncology community to the use of intravitreal pharmacotherapy in the management of radiation-related complications in uveal melanoma,” Dr Murray concluded. Timothy Murray: tmurray@murraymd.com
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