OSD in glaucoma patients


Cheryl Guttman Krader
Published: Saturday, September 22, 2018
GLAUCOMA is not just an optic neuropathy – it is also an ocular surface disease (OSD), said Florent Aptel MD, PhD.
Speaking at the 9th EuCornea Congress, Dr Aptel discussed OSD prevalence among patients with glaucoma and reviewed the etiology, diagnosis and management of OSD.
Results of several studies document that OSD is very common in glaucoma patients and show that it is related to the burden of use of medications containing preservatives. For example, one study found that more than half of glaucoma patients using two or three medications containing preservatives had signs or symptoms of OSD.
Findings from epidemiologic studies and basic science research establish benzalkonium chloride (BAK) as the primary culprit in medication-related OSD toxicity.
“Therefore, it is likely better to avoid glaucoma medications preserved with BAK, especially in patients with OSD as well as in patients who are on multidrug regimens or who will have future filtering surgery,” said Dr Aptel, professor of ophthalmology, University Hospital of Grenoble, Grenoble, France.
“Fortunately, there are several preservative-free glaucoma medications available now in both monotherapy and fixed combination options. Results of comparative studies show no differences in the IOP-lowering activity of preservative-containing and preservative-free formulations of the same active ingredient.”
Identifying the presence of OSD in patients with glaucoma should begin with a good history.
“It is very important to remember that in most patients, the symptoms of OSD precede the physical abnormalities,” Dr Aptel said.
Slit-lamp examination and fluorescein staining are generally adequate to assess for signs of OSD.
Tags: cornea, glaucoma, osd
Latest Articles
Beyond the Numbers
Empowering patient participation fosters continuous innovation in cataract surgery.
Thinking Beyond the Surgery Room
Practice management workshop focuses on financial operations and AI business applications.
Picture This: Photo Contest Winners
ESCRS 2025 Refractive and Cataract Photo Contest winners.
Aid Cuts Threaten Global Eye Care Progress
USAID closure leads retreat in development assistance.
Supplement: ESCRS Clinical Trends Series: Presbyopia
Nutrition and the Eye: A Recipe for Success
A look at the evidence for tasty ways of lowering risks and improving ocular health.
New Award to Encourage Research into Sustainable Practices
Sharing a Vision for the Future
ESCRS leaders update Trieste conference on ESCRS initiatives.
Extending Depth of Satisfaction
The ESCRS Eye Journal Club discuss a new study reviewing the causes and management of dissatisfaction after implantation of an EDOF IOL.
Conventional Versus Laser-Assisted Cataract Surgery
Evidence favours conventional technique in most cases.