EYES WITH DME FARE BETTER WITH RANIBIZUMAB IN RANDOMISED CONTROLLED TRIALS THAN IN REAL-WORLD STUDIES
A meta-analysis of 29 randomised controlled trials (RCTs) and 11 real-world studies shows that the improvements in BCVA diabetic macular oedema (DME) patients achieve over three years of treatment with ranibizumab correlates strongly with the number of the injections they receive. The analysis showed an increase in BCVA of 8.2, 9.4 and 10.3 ETDRS from baseline following 12, 24 and 36 months, respectively, of ranibizumab treatment. The largest changes in BCVA at 12 months were observed in RCTs and the smallest in real-world studies. In addition, an increase of one injection was associated with an increase in BCVA of 0.6 letters at 12 months.
M Falcão et al “Impact of Intravitreal Ranibizumab Therapy on Vision Outcomes in Diabetic Macular Edema Patients: A Meta-Analysis”, Ophthalmologica 2020, Volume 243, issue 4
OCT-A PROVIDES WINDOW TO THE KIDNEY OF DIABETIC PATIENTS
Evaluation of retinal microcirculation with optical coherence tomography angiography (OCT-A) can detect early changes related to nephropathy in type 2 diabetic patients, a new study indicates. It showed that, compared with 42 normoalbuminuric diabetic patients without retinopathy and 55 controls , 42 diabetic patients with microalbuminuria had significantly decreased mean vessel densities of the superficial capillary plexus (SCP), whole disc, and peripapillary area (p<0.05 for all). Both duration of diabetes and urinary albumin levels were significantly and moderately correlated with mean vessel density of whole SCP in diabetic patients.
V Cankurtaran et. al. “Retinal Microcirculation in Predicting Diabetic Nephropathy in Type 2 Diabetic Patients without Retinopathy”, Ophthalmologica 2020, Volume 243, issue 4.
SCLERAL BUCKLING WITH SMALL-GAUGE ENDO-ILLUMINATION PLUS HYALURONATE
A new study’s findings indicate that 25-gauge endo-illuminationaided scleral buckling (SB) combined with hyaluronate injection is a safe and effective treatment for rhegmatogenous retinal detachment (RRD). The retrospective study involved 45 RRD patients, 25 of whom underwent the new SB procedure, and 20 of whom underwent conventional SB with binocular indirect ophthalmoscope combined with air injection. The final reattachment rate was 100% in both groups. The improvements of BCVA of the treatment group and control group were –0.49 and –0.42 logMAR, respectively with no significant difference (p=0.594). However, the mean operation duration of the treatment group was significantly shorter than that of the control group (50.19min vs 42.06min, p=0.042).
T Zhao et al, “Endo-Illumination-Aided Scleral Buckling Combined with Intravitreal Injection of Hyaluronate for Treatment of Rhegmatogenous Retinal Detachment”, Ophthalmologica 2020, Volume 243, issue 4.
Ophthalmologica is the peer-reviewed journal of EURETINA
