Current understanding of pathogenesis of dry AMD still unsatisfactory
New stem cell treatment approaches entering clinical studies


Leigh Spielberg
Published: Wednesday, January 25, 2017

What we are working towards is based on the cataract surgery model, with a preloaded transplantation patch populated with an easily accessible cell sourceA large trial with a porcine model has been completed, and a phase I trial has begun in Moorfields Eye Hospital. “Previous RPE transplantation or macular translocation techniques have always used ‘old’ RPE,” said Prof da Cruz. “Here, we’re placing the overlying retina on brand new RPE. This is what we mean when we talk about regenerative medicine.” Prof da Cruz showed optical coherence tomography images of a successfully placed subretinal RPE patch with a very normal-appearing retina, including a near-physiological foveal depression, overlying it. The images seemed to give hope to delegates that they might some day be able to offer their patients a beneficial treatment option for dry AMD. Lyndon da Cruz: lyndon.dacruz@moorfields.nhs.uk
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