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Primary extranodal NK/T cell lymphoma of the orbit that was intraocular without an extraocular tumor

Poster Details

First Author: A.Okada JAPAN

Co Author(s):    Y. Harada   Y. Kiuchi                 

Abstract Details


To report a case of a primary orbital and intraocular natural killer T cell tumor without an extraocular tumor.


The Uveitis Service of Hiroshima University.


A 73-year-old female presented with blurred vision and swelling of the right eyelid. The right eyelid was swollen with conjunctival chemosis. She also suffered from inflammation in the anterior chamber with 2 cells in her right eye at the first visit.


Computed tomography and magnetic resonance imaging showed a poorly marginated mass in her right orbit which appeared to be an inflammatory pseudotumor, but there was no evidence of an extraocular tumor. The polymerase chain reaction of the anterior humor in her right eye revealed an Epstein-Barr virus infection. She was initially treated with intravenous high dose steroid therapy (1 g of methylpredonisolone), and the lid swelling deteriorated 2 days after steroid therapy. A biopsy of the right orbit was consistent with an extranodal, nasal type, NK/T cell lymphoma. After radiotherapy, her orbital tumor significantly decreased.


A few cases of NK-T cell lymphomas in ocular tissue have been reported, most of which were expansion or inversion from the nasal NK-T cell lymphoma. Primary orbital and intraocular NK/T cell lymphomas have been rarely reported. The NK/T cell lymphoma should be considered as differential diagnoses for patients with orbital tumors resistant to steroid therapy and intraocular inflammation with Epstein-Barr viral infection.

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